The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels
J. physiol. biochem
; 67(2): 217-223, jun. 2011.
Article
in English
| IBECS
| ID: ibc-122621
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
No disponible
ABSTRACT
This study was designed to examine the effects of intracerebroventricular injection of DL-AP5 (N-methyl-D-aspartate (NMDA) receptor antagonist) and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived (FD3) broiler cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were intracerebroventricularly injected with 0, 2.5, 5, and 10 nmol of DL-AP5. In experiment 2, chickens received 5 nmol DL-AP5 prior to the injection of 0.6 nmol ghrelin. In experiment 3, birds were administered with 0.6 nmol ghrelin after 300 nmol glutamate, and the cumulative feed intake was determined at 3-h postinjection. The results of this study showed that the intracerebroventricular injection of DL-AP5 increased food consumption in FD3 broiler cockerels (P ¡Ü 0.05), and this increase occurs in a dose-dependent manner. Moreover, the decreased food intake induced with the intracerebroventricular injection of ghrelin was additively enhanced by pretreatment with glutamate, and this effect was attenuated by DL-AP5 (..)(AU)
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Collection:
National databases
/
Spain
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
IBECS
Main subject:
N-Methylaspartate
/
Glutamic Acid
/
Ghrelin
Limits:
Animals
Language:
English
Journal:
J. physiol. biochem
Year:
2011
Document type:
Article
Institution/Affiliation country:
Lorestan University/Iran
/
University of Tehran/Iran