Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis
Allergol. immunopatol
; 42(3): 212-215, mayo-jun. 2014. tab
Article
in English
| IBECS
| ID: ibc-122680
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.METHODS:
Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients IL-1α −889, IL-1β −511, IL-1β +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.RESULTS:
Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p = 0.005, OR 0.14, 95%CI 0.02-0.64). The CC homozygous genotype was the most common genotype in IL-1α position −889 and IL-1β at position +3962 in both groups of patients with AD and the controls, while the TC heterozygous genotype was the most common genotype in IL-1β at position −511 and IL-1R at position Pst-I 1970, with no significant difference between the two groups.CONCLUSIONS:
This study showed a significant negative association in the IL-1R Mspa-I 11100 TT homozygous genotype in the patients with ADRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Interleukin-1
/
Polymorphism, Single Nucleotide
/
Dermatitis, Atopic
Type of study:
Risk factors
Limits:
Humans
Language:
English
Journal:
Allergol. immunopatol
Year:
2014
Document type:
Article
Institution/Affiliation country:
Children's Medical Center/Iran
/
Tehran University of Medical Sciences/Iran