Left ventricular hypertrophy induced by abdominal aortic banding and its prevention by angiotensin receptor blocker telmisartana proteomic analysis
J. physiol. biochem
; 66(4): 329-338, dic. 2010.
Article
in English
| IBECS
| ID: ibc-122820
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
No disponible
ABSTRACT
Cardiac hypertrophy is frequently caused by pressure overload (i.e., high blood pressure or hypertension) and can lead to heart failure. The major objective of the present study was to investigate the proteomic changes in response to the development of left ventricular hypertrophy(LVH) induced by abdominal aortic banding (AB) and its prevention by antihypertensive treatment with angiotensin II receptor blocker (ARB) telmisartan. One week after AB and Sham surgery, rats were assigned into three groups SHAMcontrol, aortic banding without treatment (ABCtrl) and aortic banding with telmisartan treatment (ABTelmi; 5mg/kg/day for 8 weeks). Echocardiography, hemodynamics, and pathology were performed to assess LVH. Left ventricular myocardium was sampled. The analysis of proteomic proteins from myocardium was performed by two-dimensional gel electrophoresis and MALDITOFMS. In ABCtrl, heart rate, systolic arterial blood pressure, diastolic blood pressure, left ventricular end systolic pressure, interventricular septal thickness atdiastole, posterior wall thickness in diastole, heart weight (HW) and HW/body weight (BW) were increased, indicating that both hypertension and LVH developed. Telmisartan prevented hypertension and LVH. Concurrently, among numerous proteins, there were 17 that were differentially expressed among hypertrophic hearts, normal hearts, and the hearts where hypertrophic response was suppressed by ARB treatment. Primarily, proteins involved (..) (AU)
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Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
IBECS
Main subject:
Hypertrophy, Left Ventricular
/
Proteomics
/
Angiotensin Receptor Antagonists
Limits:
Animals
Language:
English
Journal:
J. physiol. biochem
Year:
2010
Document type:
Article
Institution/Affiliation country:
Cardiovascular and Neurological Consulting Institute/USA
/
Chinese Academy of Medical Sciences and Peking Union Medical College/China