Phase II trial: concurrent radio-chemotherapy with weekly docetaxel for advanced squamous cell carcinoma of head and neck
Clin. transl. oncol. (Print)
; 9(4): 244-250, abr. 2007. tab, ilus
Article
in English
| IBECS
| ID: ibc-123299
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION:
Standard fractionation radiation therapy (RT) combined with concomitant chemotherapy (CT) based on cisplatin schemes is actually the standard treatment for locally advanced non-resectable squamous cell carcinoma of head and neck (SCCHN). The appearance of taxoids has introduced a new kind of treatment with high antitumoral power. The aim of this study is to add more information about the role of this new approach. MATERIALS ANDMETHODS:
Twenty-six patients with locally advanced non-resectable SCCHN were recruited at six institutions in Spain, between January 2001 and January 2003. Docetaxel was administered weekly, for 6 weeks, concurrently with RT.RESULTS:
The mean total delivered dose of RT was 70'2 Gy (range 64-74 Gy). The median and mean duration of time were 63 days and 61 days (range 49-103 days) respectively. After a median time control of 19 months (range 3.3-42.2 months), the response rate was 83.4%. The median time to local progression was 16.4 months (95% confidence interval [CI]=4.4-28.4 months). The median survival time was 26.9 months, with one- and two-year overall survival of 66.9% (95% CI=48.1-85.7%) and 57.5% (95% CI=37.3-77.7%) respectively. The median duration time response was 15.1 months (95% CI=3.7-26.5 months). The median time until treatment failure was 9.4 months (95% CI=4.7-14.1). Incidence of grade III-IV mucositis was 88%, neutropenia 72% and skin toxicity 92% (24% grade III-IV). The incidence of severe late toxicity (grade III and IV) due to RT/CT was 31.4%.CONCLUSIONS:
Although therapeutics results are equivalent to cisplatin schemes of concurrent CT-RT, mucositis and cutaneous toxicity registered in this trial must be considered as limiting factors to application of this new approach (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Squamous Cell
/
Taxoids
/
Head and Neck Neoplasms
/
Antineoplastic Agents
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2007
Document type:
Article
Institution/Affiliation country:
Centro Oncológico Regional de Galicia/España
/
Hospital General Universitario Gregorio Marañón/Spain
/
Hospital Ramón y Cajal/Spain
/
Hospital Reina Sofía/Spain
/
Hospital Universitario Virgen de la Arrixaca/Spain
/
Institut Clínic de Malaties Hemato-Oncològiques (ICMHO)/Spain
/
Universitat de Barcelona/Spain