Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results
Clin. transl. oncol. (Print)
; 10(10): 660-664, oct. 2008. tab
Article
in English
| IBECS
| ID: ibc-123535
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
OBJECTIVE:
To analyse the level of adherence to prophylactic surgery of breast and/or ovarian cancer in female carriers of the BRCA1 or BRCA2 mutation in a referential genetic counselling unit in Spain.METHODS:
Between January 1998 and November 2006, a total of 684 families with several cases of breast and/or ovarian cancer were selected by the Genetic Counselling Unit at the Hospital Clínico Universitario San Carlos. Some of them opted for prophylactic surgery after genetic counselling and genetic testing.RESULTS:
The pathogenic mutation was found in 57 families out of a total of 449 families who fulfilled the hereditary breast/ovarian cancer criteria. Out of a total of 238 individuals who were carriers of the mutation, 136 (57%) were offered risk-reducing prophylactic surgery. Prophylactic surgery was chosen by 58 (43%) women out of a total of 136 who were offered this possibility; the histological findings observed 7% malignant lesions in the breast and, in the ovarian-fallopian complex, 2 cases (8%) of a borderline tumour and one case (4%) of papillary adenocarcinoma.CONCLUSION:
This is the first study published on the role of prophylactic surgery in BRCA mutation carriers in the Spanish population. The incidence of occult carcinoma in these cases is lower than in other series (AU)RESUMEN
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Collection:
National databases
/
Spain
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
IBECS
Main subject:
Ovarian Neoplasms
/
Breast Neoplasms
/
Carcinoma
/
Patient Compliance
/
Genes, BRCA1
/
Genes, BRCA2
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2008
Document type:
Article
Institution/Affiliation country:
Hospital Central de Asturias/Spain
/
Hospital Clínico San Carlos/Spain
/
Hospital U niversitario Lozano Blesa/Spain