Generalised erythematous skin eruptions induced by sorafenib: cutaneous toxicity and treatment outcome
Clin. transl. oncol. (Print)
; 10(12): 844-846, dic. 2008.
Article
in English
| IBECS
| ID: ibc-123566
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
A woman diagnosed of a renal cell carcinoma in 1989 had a metastatic kidney cancer localised in subcutaneous nodules, gut and lung in 2007. Sorafenib treatment was initiated a 400 mg orally twice a day. The patient developed generalised erythematous skin eruptions and two weeks later a widespread erythematous maculopapular eruption located exclusively on the legs and arms, along with an objective response. The most likely cause of the generalised erythematous skin eruptions was considered to be sorafenib because of the close temporal relationship between exposure to the drug and onset of symptoms. Furthermore, a relationship between sorafenib skin toxicity and treatment efficacy was observed. This therapeutic efficacy of EGFR inhibitors and cutaneous side effects should be better assessed in large cohorts or trials to determine whether the skin toxicity of patients can be linked to an objective antitumour response (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pyridines
/
Benzenesulfonates
/
Carcinoma, Renal Cell
/
Dermatitis, Exfoliative
/
Kidney Neoplasms
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2008
Document type:
Article
Institution/Affiliation country:
Universidad de Valencia/Spain