Management of platinum-resistant ovarian cancer with the combination of pemetrexed and gemcitabine
Clin. transl. oncol. (Print)
; 11(1): 35-40, ene. 2009. tab, ilus
Article
in English
| IBECS
| ID: ibc-123573
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION:
Platinum resistant ovarian cancer is a current challenge in Oncology. Current approved therapies offer no more of a 20% of response. New therapeutic options are urgently needed. PATIENTS ANDMETHODS:
Patients were treated with the combination of Pemetrexed 500 mg/m(2) d1 and Gemcitabine 1000 mg/m(2) d1,8 in a 21 days basis.RESULTS:
10 platinum-resistant ovarian cancer patients were treated under compassionate use. Mean previous chemotherapy lines were 3.3. Mean administered cycles were 4. Mean CA 125 decrease was on average of 47%, with one patient experiencing a 95% decrease in her CA 125 level. 1 patient had a complete clinical remission, and 2, had partial radiological responses. Mean Progression free survival was 16.5 weeks, and Overall Survival was 21.2 weeks. Treatment was well tolerated.CONCLUSIONS:
Deemd to the observed activity, the combination of Pemetrexed and Gemcitabine deserves deeper investigation in platinum-resistant ovarian cancer patients (AU)RESUMEN
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Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Endocrine System Diseases
/
Ovary Cancer
Database:
IBECS
Main subject:
Organoplatinum Compounds
/
Ovarian Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Survival Analysis
/
Salvage Therapy
/
Drug Resistance, Neoplasm
/
Neoplasm Recurrence, Local
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2009
Document type:
Article
Institution/Affiliation country:
Clínica Universitaria de Pamplona/Spain
/
Hospital Universitari Arnau de Vilanova/Spain
/
Hospital Universitario Central de Asturias/Spain
/
Hospital Universitario Puerta de Hierro/Spain
/
Hospital de Dènia Marina Salud/Spain