Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy

Chometon, G; Jendrossek, V

Chometon, G; Jendrossek, V.

Affiliation

Chometon, G; University of Duisburg-Essen. Essen. Germany
Jendrossek, V; University of Duisburg-Essen. Essen. Germany

Clin. transl. oncol. (Print) ; 11(2): 75-81, feb. 2009. ilus, tab

Article in English | IBECS | ID: ibc-123581

Responsible library: ES1.1

Localization: BNCS

ABSTRACT
RESUMEN

ABSTRACT

The impact of a favourable microenvironment on tumour progression is a limiting factor for current tumour therapy protocols, as it contributes to the selection of resistant tumour cells. Apart from immune and inflammatory cells, the extracellular matrix, cancer-associated fibroblasts and vascular endothelial cells are crucial mediators of protective signals. An important research effort exposes potential environmental targets that may define new therapeutic strategies for solid tumours (AU)

RESUMEN

No disponible

Subject(s)

Humans; Male; Female; Neoplasms/therapy; Stromal Cells/metabolism; Drug Resistance, Neoplasm; Combined Modality Therapy; Extracellular Matrix; Fibroblasts/cytology; Fibroblasts/metabolism; Models, Biological; Neoplasms/drug therapy; Neoplasms/radiotherapy

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Collection: National databases / Spain Database: IBECS Main subject: Stromal Cells / Neoplasms Type of study: Practice guideline / Prognostic study Limits: Female / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2009 Document type: Article Institution/Affiliation country: University of Duisburg-Essen/Germany

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