Angiogenesis and ovarian cáncer
Clin. transl. oncol. (Print)
; 11(9): 564-571, sept. 2009. ilus
Article
in En
| IBECS
| ID: ibc-123678
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Ovarian carcinoma is the most important cause of gynaecological cancer-related mortality in Western societies. The age at diagnosis, extent of disease (as expressed by FIGO state), success of primary surgery and the histopathological features of the tumour are important prognostic markers. The majority of patients with ovarian cancer present with advanced disease (FIGO stage III/IV) and in this group of patients the median survival is only three years. New treatment approaches are therefore required to improve outcome in this disease. Angiogenesis, the development of a neovascular blood supply, is a critical step in the propagation of malignant tumour growth and metastasis and represents a promising target. This review will focus on angiogenesis, VEGF biology and the potential value of angiogenic factors with prognostic value in ovarian cancer (AU)
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Ovarian Neoplasms
/
Ovary
/
Prognosis
/
Carcinoma
/
Vascular Endothelial Growth Factor Receptor-1
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Neovascularization, Pathologic
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2009
Document type:
Article