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Sensibilidad a azitromicina y otros antibióticos en aislados recientes deSalmonella, Shigella y Yersinia / Susceptibility to azithromycin and other antibiotics in recent isolates of Salmonella, Shigella andYersinia
Martín-Pozo, Ángeles; Arana, David M; Fuentes, Miriam; Alós, Juan-Ignacio.
Affiliation
  • Martín-Pozo, Ángeles; Hospital Universitario de Getafe. Servicio de Microbiología. Madrid. España
  • Arana, David M; Hospital Universitario de Getafe. Servicio de Microbiología. Madrid. España
  • Fuentes, Miriam; Hospital Universitario de Getafe. Servicio de Microbiología. Madrid. España
  • Alós, Juan-Ignacio; Hospital Universitario de Getafe. Servicio de Microbiología. Madrid. España
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 32(6): 369-371, jun.-jul. 2014. tab
Article in Spanish | IBECS | ID: ibc-125106
Responsible library: ES1.1
Localization: BNCS
RESUMEN

INTRODUCCIÓN:

La azitromicina constituye una alternativa antibiótica en la diarrea bacteriana. Existen pocos datos en España de sensibilidad a azitromicina de enteropatógenos. Métodos Se determinaron las CMI de azitromicina por E-test en aislados de Salmonella no typhi (SNT), Shigella y Yersinia de los últimos 3 años (2010-2012). También se estudió la sensibilidad a los antibióticos habitualmente utilizados en la clínica diarreica mediante un método de microdilución. Resultados De las 139 cepas de SNT, Shigella y Yersinia, 138 tuvieron una CMI ≤ 16 mg/l de azitromicina. En adultos, el 14,7 y el 40,6% de las cepas de SNT y Shigella, respectivamente, mostraron resistencia al menos a 2 de los siguientes antibióticos amoxicilina, cotrimoxazol y ciprofloxacino. En población pediátrica, el 10% de los aislados de SNT y el 28,6% (2/7) de Shigella presentaron resistencia combinada a amoxicilina y cotrimoxazol. Conclusiones La azitromicina sería una elección antibiótica útil en el tratamiento de diarrea bacteriana en nuestro medio
ABSTRACT

INTRODUCTION:

Azithromycin represents an alternative option to treat bacterial diarrhea when the antibiotic therapy is indicated. Little is known regarding the susceptibility to azithromycin in enteropathogensin Spain.

METHODS:

TheMICs of azithromycin were determined by E-test against Salmonella non-typhi(SNT), Shigella and Yersinia isolates collected over the last three years (2010-2012). In addition, the susceptibility to other antibiotics usually used to treat gastrointestinal diseases was determined in these isolates by using a microdilution method.

RESULTS:

A total of 139 strains of SNT, Shigella and Yersinia were studied. All of them, except one strain, had a MIC ≤ 16 mg/L of azithromycin. In the adult population, 14.7% and 40.6% of SNT and Shigella isolates, respectively, were resistant to at least 2 of following antibiotics amoxicillin, trimethoprim-sulfamethoxazole and ciprofloxacin. In the pediatric population, 10% of SNT clinical isolates and 28.6% (2/7) of Shigella isolates were resistant to amoxicillin and trimethoprim-sulfamethoxazole.

CONCLUSIONS:

In our experience, azithromycin would be a useful antibiotic alternative to treat bacterial diarrea
Subject(s)

Full text: Available Collection: National databases / Spain Health context: Neglected Diseases Health problem: Diarrhea / Neglected Diseases / Zoonoses Database: IBECS Main subject: Salmonella / Shigella / Yersinia / Microbial Sensitivity Tests / Azithromycin Limits: Humans Language: Spanish Journal: Enferm. infecc. microbiol. clín. (Ed. impr.) Year: 2014 Document type: Article Institution/Affiliation country: Hospital Universitario de Getafe/España

Full text: Available Collection: National databases / Spain Health context: Neglected Diseases Health problem: Diarrhea / Neglected Diseases / Zoonoses Database: IBECS Main subject: Salmonella / Shigella / Yersinia / Microbial Sensitivity Tests / Azithromycin Limits: Humans Language: Spanish Journal: Enferm. infecc. microbiol. clín. (Ed. impr.) Year: 2014 Document type: Article Institution/Affiliation country: Hospital Universitario de Getafe/España
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