Elevated level of serum osteopontin in school-age children with asthma
Allergol. immunopatol
; 42(4): 275-281, jul.-ago. 2014. tab, graf
Article
in English
| IBECS
| ID: ibc-125195
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The role of osteopontin (OPN) has not been elucidated in childhood asthma.OBJECTIVE:
Our purpose was to investigate whether OPN levels change due to allergic inflammation in pre-school and school-age children.METHODS:
In this prospective, cross-sectional study, 42 healthy children and a total of 51 children with asthma were recruited. OPN levels and its association with clinical and laboratory parameters were investigated in the study population. The asthma group were divided into two groups with respect to age, ≤5-years (n = 23) and >5-years (n = 28), and labelled Asthma Group 1 and Asthma Group 2, respectively. OPN levels were compared between subgroups.RESULTS:
Serum OPN levels were significantly higher in the asthma group when compared to the control group (p = 0.004). OPN levels were similar in Asthma Group 1 and control groups, whereas it was found to be higher in Asthma Group 2 (p > 0.025, p = 0.001, respectively). In the >5-years age asthmatic group, OPN levels of the patients with allergic rhinitis (n = 15) were higher than those of the patients (n = 13) without allergic rhinitis (p = 0.021).CONCLUSION:
The study underscores the relationship between childhood asthma and OPN as the first study in the literature. In this study we found that OPN, which plays a role in Th2 mediated inflammation, may also play a role in childhood asthma. The fact that OPN levels do not increase in preschool-age children with asthma might be due to the transient wheezing in this groupRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Asthma
/
Respiratory Sounds
/
Osteopontin
Type of study:
Observational study
/
Risk factors
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2014
Document type:
Article
Institution/Affiliation country:
Fatih University Medical School/Turkey
/
Inonu University Medical School/Turkey