Prognostic significance of biochemical markers in African Burkitt's lymphoma
Clin. transl. oncol. (Print)
; 13(10): 731-736, oct. 2011. tab, ilus
Article
in English
| IBECS
| ID: ibc-125928
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND AND PURPOSE Endemic Burkitt's lymphoma (eBL) remains the prevalent form of paediatric cancer in tropical Africa with subtle pathological differences. This calls for intensified efforts to validate the global prognostic markers within local settings for improved cancer treatment and survival. This study proposes prognostic markers for enhanced eBL treatment and management. PATIENTS AND METHOD One hundred and eighty histologically and/or clinically diagnosed BL patients at Komfo Anokye Teaching Hospital, Kumasi, Ghana were eligible for this cross-sectional eight-year retrospective study. Biochemical, clinical and demographic data, before chemotherapy administration, were documented and examined for their progression-free (PFS) and overall survival (OS) significance. RESULTS A mean age of 6 (SD=2.7, range 1-16) years was observed with general male dominance (MF=1.691). Total serum lactate dehydrogenase (HR=2.04; 95% CI, 1.25-3.32; log rank=8.3; p=0.004), serum creatinine (HR=3.59; 95% CI, 1.62-7.98; log rank=15.4; p=0.002) and St. Jude stage (HR=1.74; 95% CI, 1.11-2.73; log rank=8.0; p=0.015) were important independent prognostic biochemical markers for both PFS and OS. Age, serum calcium, uric acid, potassium, sodium and phosphorus were non-prognostic. CONCLUSION The better monitoring of these prognostic indices coupled with risk-stratification treatment may improve patients' survival, especially in resource-limited settings (AU)
Search on Google
Collection:
National databases
/
Spain
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
/
SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Lymphomas and Multiple Myeloma
/
Noncommunicable Diseases
Database:
IBECS
Main subject:
Biomarkers
/
Antineoplastic Combined Chemotherapy Protocols
/
Burkitt Lymphoma
/
Cyclophosphamide
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Africa
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2011
Document type:
Article
Institution/Affiliation country:
Komfo Anokye Teaching Hospital (KATH)/China
/
Kwame Nkrumah University of Science and Technology (KNUST)/Ghana