Serum M30 and M65 values in patients with advanced stage non-small-cell lung cancer compared with controls
Clin. transl. oncol. (Print)
; 14(5): 356-361, mayo 2012. tab, ilus
Article
in English
| IBECS
| ID: ibc-126909
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
M30 and M65 are derivatives of cytokeratin 18 and released from the epithelial cell during cell death. These markers can be used to evaluate prognosis and chemotherapy response in several tumours. We evaluated serum M30 and M65 values in patients with advanced nonsmall- cell lung cancer (NSCLC) compared with those in a healthy group. MATERIAL ANDMETHODS:
Thirty-two patients with advanced NSCLC and thirty-two healthy people were included in the study. Serum M30 and M65 values were measured by quantitative ELISA method. The best cut-off value for serum M65 was calculated by ROC analysis and then univariate analysis was performed to determine the importance of M65 value in predicting progression-free survival (PFS).RESULTS:
There were no differences between mean serum M30 values between patients and controls (445.44±536.17 vs. 340.56±345.07, p=1). The mean serum M65 values were found to be significantly higher in patients than in healthy controls (1421.30±1662.59 vs. 648.85±341.17, p<0.001). The best cut-off value for serum M65 predicting PFS was 1311.64 U/l (AUC 0.58, sensitivity and specificity were 45.5% and 85.7% respectively). The patients with serum M65 values ≥1311.64 U/l had worse PFS than patients with serum M65 values <1311.64 U/l, p=0.01). There was no correlation between serum M30 value and PFS in the patient group (p=0.4).CONCLUSIONS:
Our results indicated that serum M65 values elevated in advanced NSCLC compared to a healthy control group and elevated serum M65 level can predict PFS in patients (AU)
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Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
/
Other Respiratory Diseases
/
Trachea, Bronchus, Lung Cancers
Database:
IBECS
Main subject:
Carcinoma, Non-Small-Cell Lung
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2012
Document type:
Article
Institution/Affiliation country:
Dr. Lutfi Kirdar Kartal Education and Research Hospital/Turkey
/
Siyami Ersek Thoracic and Carciovascular SurgeryHospital/turkey