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Novel antiangiogenic therapies against advanced hepatocellular carcinoma (HCC)
Pazo-Cid, RA; Lanzuela, M; Esquerdo, G; Pérez-Gracia, JL; Antón, A; Amigo, G; Trufero, JM; García-Otín, AL; Martín-Duque, P.
Affiliation
  • Pazo-Cid, RA; Miguel Servet University Hospital. Zaragoza. Spain
  • Lanzuela, M; Miguel Servet University Hospital. Zaragoza. Spain
  • Esquerdo, G; Hospital Clínica Benidorm. Benidorm. Spain
  • Pérez-Gracia, JL; Clínica Universidad de Navarra. Pamplona. Spain
  • Antón, A; Miguel Servet University Hospital. Zaragoza. Spain
  • Amigo, G; University of Santiao de Compostela. Santiago de Compostela. Spain
  • Trufero, JM; Miguel Servet University Hospital. Zaragoza. Spain
  • García-Otín, AL; Miguel Servet University Hospital. Zaragoza. Spain
  • Martín-Duque, P; Aragon Institute of Health Sciences. Zaragoza. Spain
Clin. transl. oncol. (Print) ; 14(8): 564-574, ago. 2012.
Article in English | IBECS | ID: ibc-126952
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Angiogenesis is a cornerstone in the process of hepatocarcinogenesis. In the sorafenib era, other antiangiogenic targeted drugs, such as monoclonal antibodies and a new generation of tyrosine kinase inhibitors, have been shown in phase II trials to be safe and effective in the treatment of advanced hepatocellular carcinoma. Several currently active phase III trials are testing these drugs, both in first- and second-line settings. Strategies to overcome primary and acquired resistance to antiangiogenic therapy are urgently needed. Novel biomarkers may help in improving the efficacy of drugs targeting angiogenesis (AU)
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Collection: National databases / Spain Database: IBECS Main subject: Carcinoma, Hepatocellular / Angiogenesis Inhibitors / Liver Neoplasms Type of study: Practice guideline Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2012 Document type: Article Institution/Affiliation country: Aragon Institute of Health Sciences/Spain / Clínica Universidad de Navarra/Spain / Hospital Clínica Benidorm/Spain / Miguel Servet University Hospital/Spain / University of Santiao de Compostela/Spain
Search on Google
Add to My VHL
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Collection: National databases / Spain Database: IBECS Main subject: Carcinoma, Hepatocellular / Angiogenesis Inhibitors / Liver Neoplasms Type of study: Practice guideline Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2012 Document type: Article Institution/Affiliation country: Aragon Institute of Health Sciences/Spain / Clínica Universidad de Navarra/Spain / Hospital Clínica Benidorm/Spain / Miguel Servet University Hospital/Spain / University of Santiao de Compostela/Spain