Prevalence and management of anaemia in patients with non-myeloid cancer undergoing systemic therapy: a Spanish survey
Clin. transl. oncol. (Print)
; 15(6): 477-483, jun. 2013. tab, ilus
Article
in English
| IBECS
| ID: ibc-127391
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The present study aimed to provide updated data on anaemia prevalence and management in cancer patients undergoing systemic therapy in Spain.METHODS:
This was a multicenter, observational, cross-sectional study performed in 2008. Eligible patients were ≥18 years, with non-myeloid malignancies treated with systemic therapy [chemotherapy (CT), hormonal therapy or immunotherapy]. Anaemia was defined according to WHO as haemoglobin (Hb) < 12 g/dL.RESULTS:
The study included 214 patients with a median age of 63 years (range 20-91), 58 % women, 73 % with solid tumours, and 79 % with advanced disease. CT was used in 91 % of patients (26 % with platinum compounds), hormonal therapy in 8.5 %, and immunotherapy in 8.5 %. In our study, 48.1 % of patients [95 % confidence interval (CI) 45.2-58.6] showed anaemia (31 % symptomatic) 42.0 % mild (10 ≤ Hb ≤ 11.9 g/dL), 5.6 % moderate (8 ≤ Hb ≤ 9.9 g/dL), and 0.5 % severe (Hb < 8 g/dL). A higher prevalence was observed in patients treated with CT (51 vs. 20 %, p = 0.01), platinum-based CT (70 vs. 47 %, p = 0.01) or palliative CT (61 vs. 39 %, p = 0.003). Anaemia was also more frequent in patients with more than three lines of CT (83 %) and in the fourth or subsequent CT cycle (58 %). Management in the previous 4 weeks in patients with anaemia was 62 % did not receive treatment (92 % mild), 24 % received erythropoiesis-stimulating agents (ESAs), 14 % received iron and 8.7 % received transfusion.CONCLUSIONS:
In Spanish hospitals, about half of patients with non-myeloid malignancies undergoing systemic therapy fulfilled anaemia criteria (87 % mild). Approximately two-third of patients with anaemia do not receive specific treatment and ESA use is below current guidelines (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Anemia
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Practice guideline
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2013
Document type:
Article
Institution/Affiliation country:
Clínica Ruber/Spain
/
Hospital 12 de Octubre/Spain
/
Hospital Puerta de Hierro/Spain
/
Hospital Ramón y Cajal/Spain
/
Hospital Universitario de la Princesa/Spain
/
MD Anderson Cancer Center/Spain