Profiles of circulating endothelial cells and serum cytokines during adjuvant chemoradiation in rectal cancer patients
Clin. transl. oncol. (Print)
; 15(10): 855-860, oct. 2013. tab, ilus
Article
in English
| IBECS
| ID: ibc-127511
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION:
This research aimed to demonstrate the correlation of circulating endothelial cells (CECs) count and serum cytokine levels with side effects and prognosis in rectal cancer patients receiving adjuvant chemoradiation.METHODS:
Eleven patients received proctectomy, chemoradiotherapy and follow-up for 4 years. Fifty-five blood samples were taken before radiation and during the course. The quantities of CECs were estimated by flow cytometry, and serological factors were measured by ELISA.RESULTS:
The CEC level in patients without tumor recurrence was significantly lower than in patients with tumor recurrence (p < 0.01). The IL-6 and TGF-β1 levels exhibited a similar profile (p < 0.01). For morbidity, the mean CEC level in patients with grade 3 diarrhea was significantly greater than patients with grades 1 (p < 0.001) and 2 diarrhea (p < 0.005).CONCLUSIONS:
Levels of CECs, serum IL-6, TGF-β1 and TNF-α during post-operative chemoradiation in rectal cancer patients might be candidate biomarkers for prognosis and morbidity (NCT00325871) (AU)
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Collection:
National databases
/
Spain
Health context:
Neglected Diseases
Health problem:
Diarrhea
/
Neglected Diseases
Database:
IBECS
Main subject:
Rectal Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2013
Document type:
Article
Institution/Affiliation country:
Mackay Memorial Hospital/Taiwan