Objective: tumor. Strategies of drug targeting at the tumor mass level
Clin. transl. oncol. (Print)
; 16(1): 1-10, ene. 2014. tab, ilus
Article
in English
| IBECS
| ID: ibc-127513
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Concurrent with the development of new antitumor drugs, there is intensive research to develop strategies and systems to optimize the efficacy of well-known anticancer agents. The main research lines are (a) reduction in toxicity, (b) improvement of administration and (c) overcoming drug resistance. Drug targeting systems allow us to act on these three points. The best way to increase efficacy and reduce toxicity of an anticancer agent is targeting the drug at the level of the tumor masses and maintaining its concentration there for enough time to optimize its therapeutic action. Numerous strategies have been developed to achieve this second order targeting, based on the use of polymeric-drug conjugates, polymeric micelles, liposomes and albumin conjugates and nanoparticles, whose main features of toxicity, efficacy and administration are discussed in this review (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Drug Delivery Systems
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2014
Document type:
Article
Institution/Affiliation country:
Uniiversidad Complutense de Madrid/Spain