The inmunohistochemical expression of c-Met is an independent predictor of survival in patients with lioblastoma multiforme
Clin. transl. oncol. (Print)
; 16(2): 173-177, feb. 2014. tab, ilus
Article
in English
| IBECS
| ID: ibc-127721
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND AND AIMS:
Because the outcome of glioblastoma multiforme (GBM) remains dismal, there is an urgent need for a better molecular characterization of this malignancy. The aim of this prospective study was to investigate the prognostic impact of the expression of c-mesenchymal-epithelial transition (c-Met) a receptor tyrosine kinase implicated in expression growth, survival, motility/migration, and invasion in GMB patients managed according to the established diagnostic and therapeutic protocols.METHODS:
Between May 2003 and March 2011, a total of 69 patients (33 males and 36 females; mean age 52.2 ± 12.9 years, age range 23-81 years) referred to our Department for the surgical removal of GBM were evaluated immunohistochemically for c-Met expression. Progression-free survival (PFS) and overall survival (OS) served as the main outcome measures.RESULTS:
Compared with c-Met- subjects (n = 38), c-Met+ subjects (n = 31) had both a significantly lower OS (15.3 ± 2.3 vs. 22.6 ± 2.5 months, respectively, p < 0.01) and PFS (12.3 ± 2.1 vs. 19.1 ± 2.6 months, respectively, p < 0.05). After allowance for potential confounders, multivariate Cox regression analysis identified c-Met+ as an independent predictor of both OS (hazard ratio = 1.7; 95 % confidence interval = 1.2-1.9, p < 0.01) and PFS (hazard ratio = 1.6; 95 % confidence interval = 1.1-2.3, p < 0.05).CONCLUSIONS:
Our findings suggest that c-Met immunohistochemical expression is an independent predictor of outcomes in patients with GBM treated by standard of care (AU)RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Brain Neoplasms
/
Glioblastoma
/
Proto-Oncogene Proteins c-met
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2014
Document type:
Article
Institution/Affiliation country:
Uludag University/Turkey