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Estudo sobre composição corporal, metabolismo e proteína de ligação do retinol em indivíduos infectados pelo vírus da imunodeficiência humana (HIV) de São Paulo, Brasil / Study of body composition and metabolism and retinol binding protein in human immunodeficiency virus subjects from São Paulo, Brazil
Falcoski, Carolina Agostinho; Bim, Andréia Chiodi; Beraldo, Rebeca Antunes; Kutschenko, Andressa; Ovídio, Paula Payão; Paula, Francisco José Albuquerque de; Jordão Junior, Alceu A; Vassimon, Helena Siqueira.
Affiliation
  • Falcoski, Carolina Agostinho; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. Brazil
  • Bim, Andréia Chiodi; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Beraldo, Rebeca Antunes; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Kutschenko, Andressa; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Ovídio, Paula Payão; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Paula, Francisco José Albuquerque de; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Jordão Junior, Alceu A; University of São Paulo (FMRP-USP). Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. SP. Brazil
  • Vassimon, Helena Siqueira; University of Franca. Health Promotion Program. SP. Brazil
Nutr. clín. diet. hosp ; 34(3): 64-71, sept.-dic. 2014. ilus, tab
Article in Portuguese | IBECS | ID: ibc-131753
Responsible library: ES1.1
Localization: BNCS
RESUMO

Objetivo:

Avaliar a composição corporal, metabolismo e proteína de ligação do retinol (RBP) e RBP-4 e valores de retinol em indivíduos infectados pelo HIV.

Métodos:

Homens com idades entre os 19 e60 anos foram divididos em dois grupos infectados pelo HIV (HIV+, n = 20) e não infectados pelo HIV(n = 20). Todos os indivíduos foram submetidos à absorciometria de raios-X de dupla energia (DXA) para avaliar a composição corporal e foram coletadas as amostras de sangue para medidas de retinol, RBP,RBP-4, glicose, triglicérides (TG) e lipoproteína de alta densidade (HDL).

Resultados:

O grupo HIV+ apresentou menor massa gorda em perna (18,5 ± 7%) e relação ao grupo controle (26,1 ± 6,7 %). Foram observados valores mais baixos de HDL no grupo HIV+ (29 ± 5 mg / dL) e níveis mais elevados de TG (282 ± 176) do que o controle(respectivamente 33 ± 3mg/dL, 144 ± 43 mg / dl). A proporção de TG para HDL, considerada como parâmetro para avaliar resistência insulínica foi maior no grupo HIV+ (10 ± 9) do que no grupo Controle (4 ± 1). Nenhum resultado significativofoi encontrado para diferenças entre grupos quanto aretinol, RBP e RBP-4.

Conclusão:

Indivíduos infectados pelo HIV apresentaram alterações metabólicas e de composição corporal, confirmando presença de síndrome da lipodistrofia, mas não houve diferença para o retinol, RBP e RBP-4, em comparação ao grupo controle (AU)
ABSTRACT

Objective:

To evaluate body composition, metabolism and RBP, RBP4 and retinol values in HIV-patients.

Methods:

Males aged between 19 and 60 were divided into two groups infected by HIV (HIV +, n = 20) and not infected by HIV (n = 20). All subjects were submitted to X-ray absorptiometry (DXA) to assess body composition and blood samples were collected to measured retinol, RBP, RBP-4, glucose, triglycerides (TG) and high-density lipoprotein (HDL).

Results:

The HIV + group showed significant lower fat mass on leg (18,5 ± 7%) than control (respectively 26 ± 6,7 %). It was observed lower levels of HDL in HIV+ group (29 ± 5 mg/dL), and higher levels of TG (282 ± 176) than in control group (respectively 33 ±3mg/dL, 144 ± 43 mg / dl). The ratio of TG to HDL, considered as insulin resistance parameter was higher in HIV+ group (10 ± 9) than control (4 ± 1). Neither statistical significant result was found for retinol, RBP and RBP-4.

Conclusion:

HIV patients had metabolic and body composition changes, confirming lipodystrophy syndrome, but there was no difference for retinol, RBP and RBP-4 compared to control group (AU)
Subject(s)

Full text: Available Collection: National databases / Spain Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: IBECS Main subject: Body Composition / Retinol-Binding Proteins / HIV Infections Type of study: Observational study Limits: Humans Country/Region as subject: South America / Brazil Language: Portuguese Journal: Nutr. clín. diet. hosp Year: 2014 Document type: Article Institution/Affiliation country: University of Franca/Brazil / University of São Paulo (FMRP-USP)/Brazil

Full text: Available Collection: National databases / Spain Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: IBECS Main subject: Body Composition / Retinol-Binding Proteins / HIV Infections Type of study: Observational study Limits: Humans Country/Region as subject: South America / Brazil Language: Portuguese Journal: Nutr. clín. diet. hosp Year: 2014 Document type: Article Institution/Affiliation country: University of Franca/Brazil / University of São Paulo (FMRP-USP)/Brazil
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