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The clinical significance of CDK1 expression in oral squamous cell carcinoma
Chen, Xin; Zhang, Feng-He; Chen, Qiao-Er; Wang, Yuan-Yin; Wang, Yin-Long; He, Jia-Cai; Zhou, Jian.
Affiliation
  • Chen, Xin; Anhui Medical University. College and Hospital of Stomatology (Oral clinical medicine key discipline of Anhui province, oral disease research provincial laboratory of Anhui province, the central and local governments construction center laboratory of stomatology). China
  • Zhang, Feng-He; Shandong provincial key laboratory of oral biomedicine. Shandong University. College and Hospital of Stomatology. China
  • Chen, Qiao-Er; Anhui Medical University. College and Hospital of Stomatology. Department of Pathology. China
  • Wang, Yuan-Yin; Anhui Medical University. College and Hospital of Stomatology. Department of Oral and Maxillofacial Surgery. China
  • Wang, Yin-Long; Anhui Medical University. College and Hospital of Stomatology. Department of Oral and Maxillofacial Surgery. China
  • He, Jia-Cai; Anhui Medical University. College and Hospital of Stomatology. Department of Oral and Maxillofacial Surgery. China
  • Zhou, Jian; Anhui Medical University. College and Hospital of Stomatology. Department of Oral and Maxillofacial Surgery. China
Med. oral patol. oral cir. bucal (Internet) ; 20(1): e7-e12, ene. 2015. ilus, tab
Article in English | IBECS | ID: ibc-132050
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
China

OBJECTIVES:

To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Study

DESIGN:

Immunohistochemical expression of CDK1 was compared with various clinic pathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated.

RESULTS:

The CDK1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60controlled (35.0%). The expression of CDK1 was significantly correlated with the histological grade of OSCC(P<0.05). The CDK1 protein was over-expressed in recurrent tumors or in those with lymph node metastasis. Statistical analysis showed a significant reduction in the 5-year accumulative survival rate in CDK1 positive cases compared with CDK1 negative cases (P<0.05). Namely, the CDK1 positive patients had poor prognosis.

CONCLUSIONS:

The expression of CDK1 might serve as malignant degree and prognostic markers for the survival of OSCC
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / CDC2 Protein Kinase Limits: Humans Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2015 Document type: Article Institution/Affiliation country: Anhui Medical University/China / Shandong provincial key laboratory of oral biomedicine/China
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / CDC2 Protein Kinase Limits: Humans Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2015 Document type: Article Institution/Affiliation country: Anhui Medical University/China / Shandong provincial key laboratory of oral biomedicine/China