Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells
Med. oral patol. oral cir. bucal (Internet)
; 20(2): e180-e187, mar. 2015. ilus
Article
in English
| IBECS
| ID: ibc-134130
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
OBJECTIVES:
Abnormal cellular immune response has been considered to be responsible for oral lesions in recurrent aphthous stomatitis. Zinc has been known to be an essential nutrient metal that is necessary for a broad range of biological activities including antioxidant, immune mediator, and anti-inflammatory drugs in oral mucosal disease. The objective of this study was to investigate the effects of zinc in a phorbol-12-myristate-13-acetate (PMA)-treated inflammatory model on human gingival fibroblast cells (hGFs).StudyDESIGN:
Cells were pre-treated with zinc chloride, followed by PMA in hGFs. The effects were assessed on cell viability, cyclooxygenease-1,2(COX-1/2) protein expression, PGE2 release, ROS production and cytokine release,RESULTS:
The effects were assessed on cell viability, COX1/2 protein expression, PGE2 release, ROS production, cytokine release. The results showed that, in the presence of PMA, zinc treatment leads to reduce the production of ROS, which results in decrease of COX-2 expression and PGE2 release.CONCLUSIONS:
Thus, we suggest that zinc treatment leads to the mitigation of oral inflammation and may prove to be an alternative treatment for recurrent aphthous stomatitis
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Stomatitis, Aphthous
/
Zinc Compounds
/
Fibroblasts
Limits:
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2015
Document type:
Article
Institution/Affiliation country:
Chonnam National University hospital/Korea
/
Chonnam National University/Korea
/
Su Dental Clinical Research Center/Korea