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Quantification of circulating endothelial cells as a predictor of response to chemotherapy with platinum and pemetrexed in patients with advanced non-squamous non-small cell lung carcinoma
Sánchez Hernández, Alfredo; José Juan, Oscar; Vidal Martínez, José; Blanco, Remei; Maciá, Sonia; Esquerdo Galiana, Gaspar; Aparisi Aparisi, Francisco; Garde Noguera, Javier; Catot, Silvia; Losa Gaspá, Ferran; García-Piñon, Francisco.
Affiliation
  • Sánchez Hernández, Alfredo; Consorcio Hospitalario Provincial de Castellón. Servicio de Oncología Médica. Castellón. Spain
  • José Juan, Oscar; Hospital Universitari I Politècnic la Fé. Servicio de Oncología Médica. Valencia. Spain
  • Vidal Martínez, José; Hospital Arnau de Vilanova. Servicio de Análisis Clínicos. Valencia. Spain
  • Blanco, Remei; Hospital Mútua de Terrassa. Servicio de Oncología Médica. Terrassa. Spain
  • Maciá, Sonia; Hospital General de Elda. Servicio de Oncología Médica. Elda. Spain
  • Esquerdo Galiana, Gaspar; Clinica de Benidorm. Servicio de Oncología Médica. Benidorm. Spain
  • Aparisi Aparisi, Francisco; Hospital Virgen de los Lirios. Servicio de Oncología Médica. Alcoy. Spain
  • Garde Noguera, Javier; Hospital Arnau de Vilanova. Servicio de Oncología Médica. Valencia. Spain
  • Catot, Silvia; Clinica Althaia de Manresa. Servicio de Oncología Médica. Manresa. Spain
  • Losa Gaspá, Ferran; Hospital Sant Joan d’Espí-Moises Broggi. Servicio de Oncología Médica. Sant Joan Despí. Spain
  • García-Piñon, Francisco; Hospital Provincial de Castellón. Castellón. Spain
Clin. transl. oncol. (Print) ; 17(4): 281-288, abr. 2015. tab, graf
Article in English | IBECS | ID: ibc-134247
Responsible library: ES1.1
Localization: BNCS
ABSTRACT

Introduction:

Circulating endothelial cells (CEC) play an important role in tumor neovascularization and may have prognostic value in cancer patients. This study was designed to investigate the role of CEC as a marker for predicting platinum plus pemetrexed first-line chemotherapy efficacy in advanced non-squamous non-small cell lung cancer (NSCLC).

Methods:

A prospective study was performed whose main objective was to study whether the numbers of CEC at baseline and prior to the second and third cycle of chemotherapy were response predictors. Sixty-nine patients received cisplatin plus pemetrexed, and peripheral blood samples were performed at baseline and after second and third cycle. Separation and CEC count were performed using inmunomagnetic separation (CellSearch).

Results:

The CEC count in 4 mL of peripheral blood was obtained prior to the first, second, and third cycle of treatment. Baseline levels and evolution of CEC were correlated with response to treatment according to RECIST criteria after three cycles of treatment. Sixty-nine patients were included 43 (64.2 %) received cisplatin/pemetrexed and 24 (35.8 %) carboplatin/pemetrexed. Range of baseline CEC 8–965 (mean of 153 cel/4 mL). The results after 3 cycles were 25 partial responses (36.2 %), 17 cases of stabilization of disease (24.6 %), 16 of progressive disease (23.2 %) and 11 non-evaluables (16 %). No significant relationship between the baseline CEC count and response was found (p value = 0.831). Increase >50 % between the first and second cycle was correlated significantly with progression disease (p = 0.008). Patients who had a baseline CEC count greater than the mean (>153 cells/4 mL) showed longer progression-free survival and global survival without statistical significance.

Conclusions:

In this homogeneous group of patients with NSCLC, there is no correlation between response to treatment and CEC baseline levels. The increase in CEC numbers after the first cycle could be a negative predictive factor (AU)
RESUMEN
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Collection: National databases / Spain Database: IBECS Main subject: Endothelial Cells / Lung Neoplasms / Antineoplastic Agents Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2015 Document type: Article Institution/Affiliation country: Clinica Althaia de Manresa/Spain / Clinica de Benidorm/Spain / Consorcio Hospitalario Provincial de Castellón/Spain / Hospital Arnau de Vilanova/Spain / Hospital General de Elda/Spain / Hospital Mútua de Terrassa/Spain / Hospital Provincial de Castellón/Spain / Hospital Sant Joan d’Espí-Moises Broggi/Spain / Hospital Universitari I Politècnic la Fé/Spain / Hospital Virgen de los Lirios/Spain
Search on Google
Collection: National databases / Spain Database: IBECS Main subject: Endothelial Cells / Lung Neoplasms / Antineoplastic Agents Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2015 Document type: Article Institution/Affiliation country: Clinica Althaia de Manresa/Spain / Clinica de Benidorm/Spain / Consorcio Hospitalario Provincial de Castellón/Spain / Hospital Arnau de Vilanova/Spain / Hospital General de Elda/Spain / Hospital Mútua de Terrassa/Spain / Hospital Provincial de Castellón/Spain / Hospital Sant Joan d’Espí-Moises Broggi/Spain / Hospital Universitari I Politècnic la Fé/Spain / Hospital Virgen de los Lirios/Spain
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