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A study comparing two consecutive historical periods in breast cancer with a focus on surgical treatment, loco-regional recurrence, distant metastases and mortality
García-Fernández, A; Chabrera, C; García-Font, M; Fraile, M; Barco, I; González, S; Cirera, L; Lain, JM; González, C; Veloso, E; Codina, L; Piqueras, M; Pessarrodona, A; Gimenez, N.
Affiliation
  • García-Fernández, A; Catalan Institute of Health. Department of Gynecology. Mollet del Vallès. Spain
  • Chabrera, C; School of Health Science TecnoCampus. Department of Nursing. Barcelona. Spain
  • García-Font, M; University International of Catalunya. Barcelona. Spain
  • Fraile, M; University Hospital of Mútua Terrassa. Nuclear Medicine Department-CTD. Terrassa. Spain
  • Barco, I; University Hospital of Mútua Terrassa. Department of Gynecology. Breast Unit. Terrassa. Spain
  • González, S; University Hospital of Mútua Terrassa. Department of Hemato-oncology. Terrassa. Spain
  • Cirera, L; University Hospital of Mútua Terrassa. Department of Hemato-oncology. Terrassa. Spain
  • Lain, JM; Hospital of Terrassa. Department of Gynecology. Breast Unit. Terrassa. Spain
  • González, C; University Hospital of Mútua Terrassa. Department of Pathology. Terrassa. Spain
  • Veloso, E; University Hospital of Mútua Terrassa. Department of Surgery. Terrassa. Spain
  • Codina, L; University Hospital of Mútua Terrassa. Department of Gynecology. Terrassa. Spain
  • Piqueras, M; University Hospital of Mútua Terrassa. Department of Gynecology. Terrassa. Spain
  • Pessarrodona, A; University Hospital of Mútua Terrassa. Department of Gynecology. Terrassa. Spain
  • Gimenez, N; University of Barcelona. Research Foundation Mútua Terrassa. Research Unit. Barcelona. Spain
Clin. transl. oncol. (Print) ; 17(4): 296-305, abr. 2015. tab, graf
Article in English | IBECS | ID: ibc-134249
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Background and

aim:

Recent introduction of breast units, mass-screening programmes (SP) and sentinel node biopsy (SNB) has impacted on the clinical care of breast cancer patients (BC), resulting in a significant increase of breast-conserving surgery with the goal of achieving completely free margins and good cosmetic outcome, along with significantly less axillary morbidity. In order to ascertain the combined impact of SP and SNB on BC patients, we have reviewed the primary therapeutic approach of patients diagnosed with invasive breast carcinoma in our centre, both before and after implementation of the two new procedures.

Methods:

1,942 patients operated for BC between 1997 and 2013 in two clinical centres. Two historical periods were considered before and after the advent of the Breast Unit in our institutions and the concurrent implementation of SP and SNB (September 2002).

Results:

Rates of breast-conserving surgery and re-operations improved in the second period. Intraoperative margin re-excision increased in the second period. Breast-conserving surgery decreased in parallel to stage from 79 % for stage I to 31 % for stage III. The Cox analysis, including stage as adjusted for all significant variables, showed statistically significant differences in favour of the initial stages but only for specific mortality, not overall mortality.

Conclusions:

Combined implementation of breast units, SP, and SNB have resulted in a significant improvement of BC treatment leading to increased rates of breast-conserving surgery and decreased disease recurrence and mortality (AU)
RESUMEN
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Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Breast Neoplasms / Neoplasm Metastasis / Neoplasm Recurrence, Local Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Female / Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2015 Document type: Article Institution/Affiliation country: Catalan Institute of Health/Spain / Hospital of Terrassa/Spain / School of Health Science TecnoCampus/Spain / University Hospital of Mútua Terrassa/Spain / University International of Catalunya/Spain / University of Barcelona/Spain
Search on Google
Collection: National databases / Spain Database: IBECS Main subject: Breast Neoplasms / Neoplasm Metastasis / Neoplasm Recurrence, Local Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Female / Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2015 Document type: Article Institution/Affiliation country: Catalan Institute of Health/Spain / Hospital of Terrassa/Spain / School of Health Science TecnoCampus/Spain / University Hospital of Mútua Terrassa/Spain / University International of Catalunya/Spain / University of Barcelona/Spain
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