Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: a histomorphometric and radiodensitometric study
Med. oral patol. oral cir. bucal (Internet)
; 20(4): e489-e493, jul. 2015. ilus
Article
in English
| IBECS
| ID: ibc-138977
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate the effects of intermittent treatment of parathyroid hormone (PTH (1-34)) on the bone regeneration of critically-sized rat calvarial bone defects. MATERIAL ANDMETHODS:
Thirty-two male rats were trephined (4mm fullthickness diameter), in the central part of the parietal bones and divided into 2 groups of 16. The PTH group received subcutaneous injections of PTH (1-34) at 40μg/kg, 3 times a week and the control (CTL) group received the vehicle in the same regimen. The rats were sacrificed at 4 weeks post-treatment regimen, the parietal bones were extracted and samples were evaluated through histomorphometry and radiodensitometry.RESULTS:
The histological observations showed that the PTH group presented more "island-like" new bone between the defect margins with fibrous tissues than did the CTL group. The PTH group significantly exhibited greater histologic bone formation than did the CTL group (1.5mm ±0.7; 1.9 mm ± 0.6, p < 0.05/ for residual bone defect). The radiodensitometry analysis revealed significant differences among the PTH and CTL groups (2.1 Al eq. ±0.04; 1.8Al eq. ±0.06, p < 0.05), demonstrating an increase in bone mineral density. The PTH treatment contributed to the bone formation with a higher amount of mineral and/or fibrous tissue when compared with the CTL group.CONCLUSIONS:
The results suggest that it was possible to increase the process of bone regeneration by accelerating the healing process in rat calvarial defects through intermittent administration of the PTH treatment
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Parathyroid Hormone
/
Parietal Bone
/
Bone Regeneration
/
Densitometry
Limits:
Animals
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2015
Document type:
Article
Institution/Affiliation country:
Federal University of Campina Grande/Brazil
/
Federal University of Piauí/Brazil
/
Pontificial Catholic University of Minas Gerais/Brazil
/
University of Campinas/Brazil
/
University of North Carolina/USA