Optimación de estrategias en el manejo de la infección por el CMV en el trasplante / Optimization strategies in management of CMV infection in transplant patients
Rev. esp. quimioter
; 28(supl.1): 52-53, sept. 2015.
Article
in Spanish
| IBECS
| ID: ibc-140932
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
En la actualidad se emplean dos estrategias terapéuticas para prevenir el desarrollo de enfermedad orgánica por el CMV en el paciente trasplantado, la profilaxis universal y el tratamiento anticipado. Ambas son potencialmente optimizables. La primera, identificando con precisión a los pacientes con máximo riesgo de viremia con objeto de tratarlos selectivamente (profilaxis dirigida). En este sentido disponemos de marcadores genotípicos, biológicos en inmunológicos que podrían permitirlo. La segunda, a través de la monitorización conjunta de la carga viral del CMV en plasma y del nivel de LT CD8+ y CD4+ productores de IFN-g específicos frente al CMV (AU)
ABSTRACT
Currently, two therapeutic strategies are applied for preventing the development of CMV end-organ disease in transplant recipients universal prophylaxis and preemptive antiviral therapy. Both are potentially optimable. As for the former strategy, precisely identifying patients at greatest risk of viremia would allow for a targeted prophylaxis. In this sense several genotypic, immunological and biological markers have been described that could be ancillary to that purpose. As for the latter strategy, combined monitoring of plasma CMV DNA load and peripheral levels of CMV-specific CD8 + and CD4 + IFN-γ producing T cells would permit a more rationale use of antivirals, thus avoiding overtreatment and derived toxicity (AU)
Full text:
Available
Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
Database:
IBECS
Main subject:
Transplantation
/
Health Strategies
/
Infection Control
/
Antibiotic Prophylaxis
/
Bocavirus
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. esp. quimioter
Year:
2015
Document type:
Article
Institution/Affiliation country:
Universitat de Valencia/España