Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study
Med. oral patol. oral cir. bucal (Internet)
; 20(6): e737-e743, nov. 2015. tab, ilus
Article
in English
| IBECS
| ID: ibc-144707
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients. MATERIAL ANDMETHODS:
A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.RESULTS:
The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (p = 0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.CONCLUSIONS:
IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis
Full text:
Available
Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
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Target 3.5: Prevention and treatment of consumption of psychoactive substances
Database:
IBECS
Main subject:
Tobacco Use Disorder
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Smoking
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Interleukin-1
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Receptors, Interleukin-1 Type I
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Peri-Implantitis
Type of study:
Etiology study
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Observational study
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Prognostic study
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Risk factors
Limits:
Adult
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Female
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Humans
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Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2015
Document type:
Article
Institution/Affiliation country:
University of Barcelona/Spain
/
University os Barcelona/Spain