Twist as a new prognostic marker in hematological malignancies
Clin. transl. oncol. (Print)
; 18(2): 113-124, feb. 2016. ilus
Article
in English
| IBECS
| ID: ibc-148215
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Twist proteins are members of basic helix-loop-helix family and are major regulators of embryogenesis. In adult humans, Twist proteins are mainly expressed in precursor cells, including myogenic, osteoblastic, chondroblastic and myelomonocytic lineages, maintaining their undifferentiated state. In addition, they play important roles in lymphocyte function and maturation. Recently, several studies have reported regulatory roles for Twist in the function and development of hematopoietic cells as well as in survival and development of numerous hematological malignancies. It is activated by numerous signal transduction pathways, including Akt, nuclear factor κB, Wnt, signal transducer and activator of transcription 3, mitogen-activated protein kinase and Ras signaling. Activated Twist has an anti-apoptotic role and protects cancer cells from apoptotic cell death. In addition, overexpression of Twist promotes the process of epithelial-mesenchymal transition, which has an essential role in cancer metastasis. Hereby, we review the aberrant expression of Twist in hematopoietic malignancies such as leukemias, lymphomas and myelodysplastic syndrome, which is related with poor prognosis and drug resistance in these disorders. Inactivation of Twist by small RNAs technology or chemotherapeutic inhibitors targeting Twist and upstream or downstream molecules of Twist signaling pathways may be helpful in management of disease to improve treatment strategies in malignancies (AU)
RESUMEN
No disponible
Search on Google
Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Leukemia
Database:
IBECS
Main subject:
Biomarkers
/
Leukemia
/
Protamine Kinase
/
Bone Marrow Neoplasms
/
Hematologic Neoplasms
/
Epithelium
/
Stem Cell Niche
Type of study:
Evaluation study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article
Institution/Affiliation country:
Ahvaz Jundishapur University of Medical Sciences/Iran
/
Semnan University of Medical Sciences/Iran