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Twist as a new prognostic marker in hematological malignancies
Norozi, F; Ahmadzadeh, A; Shahjahani, M; Shahrabi, S; Saki, N.
Affiliation
  • Norozi, F; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Ahmadzadeh, A; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Shahjahani, M; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Shahrabi, S; Semnan University of Medical Sciences. Faculty of Medicine. Department of Biochemistry and Hematology. Semnan. Iran
  • Saki, N; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
Clin. transl. oncol. (Print) ; 18(2): 113-124, feb. 2016. ilus
Article in English | IBECS | ID: ibc-148215
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Twist proteins are members of basic helix-loop-helix family and are major regulators of embryogenesis. In adult humans, Twist proteins are mainly expressed in precursor cells, including myogenic, osteoblastic, chondroblastic and myelomonocytic lineages, maintaining their undifferentiated state. In addition, they play important roles in lymphocyte function and maturation. Recently, several studies have reported regulatory roles for Twist in the function and development of hematopoietic cells as well as in survival and development of numerous hematological malignancies. It is activated by numerous signal transduction pathways, including Akt, nuclear factor κB, Wnt, signal transducer and activator of transcription 3, mitogen-activated protein kinase and Ras signaling. Activated Twist has an anti-apoptotic role and protects cancer cells from apoptotic cell death. In addition, overexpression of Twist promotes the process of epithelial-mesenchymal transition, which has an essential role in cancer metastasis. Hereby, we review the aberrant expression of Twist in hematopoietic malignancies such as leukemias, lymphomas and myelodysplastic syndrome, which is related with poor prognosis and drug resistance in these disorders. Inactivation of Twist by small RNAs technology or chemotherapeutic inhibitors targeting Twist and upstream or downstream molecules of Twist signaling pathways may be helpful in management of disease to improve treatment strategies in malignancies (AU)
RESUMEN
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Collection: National databases / Spain Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Leukemia Database: IBECS Main subject: Biomarkers / Leukemia / Protamine Kinase / Bone Marrow Neoplasms / Hematologic Neoplasms / Epithelium / Stem Cell Niche Type of study: Evaluation study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / Semnan University of Medical Sciences/Iran
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Collection: National databases / Spain Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Leukemia Database: IBECS Main subject: Biomarkers / Leukemia / Protamine Kinase / Bone Marrow Neoplasms / Hematologic Neoplasms / Epithelium / Stem Cell Niche Type of study: Evaluation study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / Semnan University of Medical Sciences/Iran
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