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Central nervous system niche involvement in the leukemia
Heidari, N; Saki, N; Filippis, L de; Shahjahani, M; Teimouri, A; Ahmadzadeh, A.
Affiliation
  • Heidari, N; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Saki, N; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Filippis, L de; Rutgers University. Child Health Institute of New Jersey. New Brunswick. USA
  • Shahjahani, M; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
  • Teimouri, A; Ahvaz Jundishapur University of Medical Sciences. Department of Neurosurgery. Ahvaz. Iran
  • Ahmadzadeh, A; Ahvaz Jundishapur University of Medical Sciences. Health Research Institute. Research Center of Thalassemia and Hemoglobinopathy. Ahvaz. Iran
Clin. transl. oncol. (Print) ; 18(3): 240-250, mar. 2016. tab, ilus
Article in English | IBECS | ID: ibc-148707
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Central nervous system (CNS) impairment is commonly involved in leukemia, as it can be observed upon onset or relapse of the disease. It is associated with poor prognosis and is a challenging clinical problem. The objective of this paper was to provide a characterization of the CNS niche in leukemia, to elucidate the culprits of CNS involvement, including diagnostic micro RNAs (miRs) and early leukemia prognosis. CNS niche is a proper location for homing of leukemic stem cells, thus representing a candidate target in the treatment of leukemia. Recent advances in the study of leukemia hallmarks have enlightened miRs as novel biomarkers for diagnosis and detection of CNS involvement in leukemia, thus providing the opportunity to develop novel therapeutic approaches. Given the importance of prognosis and early diagnosis of CNS involvement in leukemias as well as the severe side effects of current treatments, diagnostic and therapeutic approaches should focus on identification and inhibition of the factors contributing to CNS involvement, including CXCR3, P-selectin glycoprotein ligand-1 and MCP1. MiRs such as miR-221 and miR-222 are emerging as potential tools for an innovative non-invasive therapy of CNS in leukemia affected patients (AU)
RESUMEN
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Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Therapeutics / Philadelphia Chromosome / Biomarkers / Leukemia / Central Nervous System / Cerebrospinal Fluid / Stem Cell Niche / Noninvasive Ventilation Type of study: Prognostic study / Screening study Limits: Female / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / Rutgers University/USA
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Collection: National databases / Spain Database: IBECS Main subject: Therapeutics / Philadelphia Chromosome / Biomarkers / Leukemia / Central Nervous System / Cerebrospinal Fluid / Stem Cell Niche / Noninvasive Ventilation Type of study: Prognostic study / Screening study Limits: Female / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / Rutgers University/USA
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