Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis
Allergol. immunopatol
; 44(2): 125-130, mar.-abr. 2016. tab
Article
in English
| IBECS
| ID: ibc-150659
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR. MATERIALS ANDMETHODS:
Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method.RESULTS:
A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL-10 gene were found with higher frequencies in patients than controls. Patients with CC genotype in rs1800871 in Il-10 had significantly lower levels of IgE.CONCLUSION:
We found that certain genetic variants in IL-10 and TGF-β polymorphisms were associated with susceptibility to AR as well as some clinical parameters in the patients with ARRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Interleukin-10
/
Polymorphism, Single Nucleotide
/
Transforming Growth Factor beta1
/
Rhinitis, Allergic
Type of study:
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2016
Document type:
Article
Institution/Affiliation country:
Iran University of Medical Science/Iran
/
Kurdistan University of Medical Sciences/Iran
/
Tehran University of Medical Sciences/Iran
/
Universal Scientific Education and Research Network (USERN)/Iran