Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution
Clin. transl. oncol. (Print)
; 18(5): 537-540, mayo 2016. tab, ilus
Article
in English
| IBECS
| ID: ibc-151189
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Purpose:
To evaluate the features of bone marrow (BM) biopsy involvement by lymphoma, pattern of infiltration, morphological analysis and flow cytometry were reviewed at all lymphoma patients over a period of 10 years. Methods/patients 413 cases were included in the study if BM biopsy slides were available. Only 356 patients had both BM trephine biopsy and flow cytometry.Results:
The most frequent subtype was diffuse large B cell (31.2 %), followed by follicular lymphoma (18.9 %). The predominant pattern was mixed (nodular-interstitial) (9.2 %). Morphological marrow infiltration was found in 138 cases, and flow cytometry identified 117 cases with BM involvement. A concordance between the two methods was detected in 305 cases (85.7 %). There was discordance in 51 cases (14.3 %) morphology positive/FC negative in 33 cases and morphology negative/FC positive in 18.Conclusions:
Flow cytometry is slightly more useful in detecting involvement when the BM is affected, but this finding is not conclusive (AU)RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Biopsy
/
Bone Marrow
/
Flow Cytometry
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article
Institution/Affiliation country:
Hospital Universitario Fundación Alcorcón/Spain