Exhaled nitric oxide in relation to asthma control: A real-life survey
Allergol. immunopatol
; 44(3): 197-205, mayo-jun. 2016. tab, graf
Article
in English
| IBECS
| ID: ibc-152074
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Asthma is characterised by chronic airway inflammation, a complex cascade of events, mostly sustained by eosinophil recruitment and activation. Fractional exhaled nitric oxide (FeNO) is a surrogate marker of airway inflammation closely associated with bronchial eosinophilia. FeNO is used to define asthma phenotype, to assess eosinophilic inflammatory severity and to predict corticosteroid responsiveness.OBJECTIVE:
The aim of this study was to investigate whether FeNO may be associated with some clinical and functional factors in asthmatics evaluated in a real life setting.METHODS:
Globally 363 patients (150 males, mean age 46.3 years) with asthma were consecutively evaluated. The following parameters were assessed history, including comorbidities, physical examination, body mass index (BMI), lung function, asthma control grade, asthma control test (ACT), and FeNO.RESULTS:
FeNO values were significantly higher in patients with poorly controlled asthma (p < 0.01), asthma symptoms (p = 0.015), wheezing (p < 0.001), rhinitis diagnosis, (p = 0.049) and rhinitis symptoms (p = 0.019), but lower in patients with GERD (p = 0.024) and pneumonia history (p = 0.048). FeNO values increased in patients with the lowest corticosteroid dose (p = 0.031). FeNO values > 25 ppb were associated with poorly controlled asthma (OR 3.71), asthma signs (OR 3.5) and symptoms (OR 1.79). A FeNO value cut-off of 29.9 ppb was fairly predictive of (AUC 0.7) poorly controlled asthma.CONCLUSIONS:
FeNO assessment in clinical practice may be a useful tool for monitoring asthmatics as it is associated with several clinical factors, including asthma controlRESUMEN
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Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
IBECS
Main subject:
Asthma
/
Biomarkers
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Rhinitis
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Nitric Oxide
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Adult
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Female
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Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2016
Document type:
Article
Institution/Affiliation country:
IRCCS-Azienda Ospedaliera Universtiaria San Marino/Italy
/
University of Genoa/Italy
/
University of Torino/Italy