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Clinical significance of cellular and acellular mucin pools in rectal carcinoma following preoperative chemoradiotherapy
Cienfuegos, JA; Baixauli, J; Rotellar, F; Arredondo, J; Sola, JJ; Arbea, L; Pastor, C; Hernández-Lizoáin, JL.
Affiliation
  • Cienfuegos, JA; University of Navarra. School of Medicine. Pamplona. Spain
  • Baixauli, J; University of Navarra. School of Medicine. Pamplona. Spain
  • Rotellar, F; University of Navarra. School of Medicine. Pamplona. Spain
  • Arredondo, J; Complejo Hospitalario de León. Department of General Surgery. León. Spain
  • Sola, JJ; University of Navarra. School of Medicine. Pamplona. Spain
  • Arbea, L; University of Navarra. School of Medicine. Pamplona. Spain
  • Pastor, C; The Autonomous University of Madrid. Fundación Jiménez Díaz. Madrid. Spain
  • Hernández-Lizoáin, JL; University of Navarra. School of Medicine. Pamplona. Spain
Clin. transl. oncol. (Print) ; 18(7): 714-721, jul. 2016. tab, ilus, graf
Article in English | IBECS | ID: ibc-153497
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Background and

objectives:

The standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (CRT) followed by surgery. Pathological findings remain the most significant prognostic factor. The presence of mucin pools and their prognostic significance is a controversial issue. The aim of this study was to analyze the incidence of cellular and acellular mucin pools and their clinical significance.

Methods:

Four-hundred and forty-six consecutive prospectively collected specimens from patients with LARC treated with long-course preoperative CRT and surgery were analyzed. Kaplan-Meier analysis was performed.

Results:

Mucin pools were present in 182 specimens (40.8 %); 66 (14.7 %) were acellular, and viable tumor cells were identified in 116 (26 %). The complete pathological response rate was 13.5 % (60 of 446). With a median follow-up of 79.0 months, the 5- and 10-year disease-free survivals for patients with acellular and cellular mucin pools were 81.5, 78.1, 63.7 and 61.2 %, respectively (p B 0.026). The presence of cells in the colloid response to treatment was associated with a 17.8 and 16.9 % decrease in 5- and 10-year disease survival vs. acellular colloid response.

Conclusions:

Our results suggest that cellular mucin pools are an indicator of an aggressive phenotype and harbingers of a worse prognosis (AU)
RESUMEN
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Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Rectal Neoplasms / Carcinoma / Adenocarcinoma / Neoadjuvant Therapy / Mucins Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Complejo Hospitalario de León/Spain / The Autonomous University of Madrid/Spain / University of Navarra/Spain
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Collection: National databases / Spain Database: IBECS Main subject: Rectal Neoplasms / Carcinoma / Adenocarcinoma / Neoadjuvant Therapy / Mucins Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Language: English Journal: Clin. transl. oncol. (Print) Year: 2016 Document type: Article Institution/Affiliation country: Complejo Hospitalario de León/Spain / The Autonomous University of Madrid/Spain / University of Navarra/Spain
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