Quality of life in patients treated by adjuvant radiotherapy for endometrial and cervical cancers: correlation with dose-volume parameters
Clin. transl. oncol. (Print)
; 18(9): 901-908, sept. 2016. tab, graf
Article
in English
| IBECS
| ID: ibc-155504
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Introduction:
Modern multidisciplinary cancer treatments aim at obtaining minimal influence on patients quality of life (QoL). The purpose of this study was to assess QoL and correlate it with dose-volume parameters of organ at risks (OARs) in patients who received adjuvant radiotherapy for endometrial and cervical cancers. Materials andmethods:
We administered the EORTC QLQ-C30 and EN24 or CX24 questionnaires to 124 patients, 100 with endometrial cancer and 24 with cervical cancer treated with postoperative radiotherapy ± chemotherapy in regular follow-up. Bladder function, fecal incontinence or urgency and sexual functioning were investigated and correlated with dose-volume parameters of OAR by multiple linear regression analysis. This correlation was assessed by R2 value.Results:
QoL was very high in the majority of patients (82.3 % of patients). Few patients referred urinary incontinence (3.2 %) or abdominal discomfort of high grade (4.0 %). We found a significant correlation between bladder V40, i.e., absolute percentage of bladder volume that received a dose of 40 Gy, and global health status (p < 0.05, R 2 = 0.17), urinary urgency (p < 0.05, R 2 = 0.24), urinary incontinence (p < 0.05, R 2 = 0.23) and dyspareunia (p < 0.05, R 2 = 0.04). We found also a correlation between global health status and mean dose to vagina (p < 0.05, R 2 = 0.17) and between maximum dose to lumbo-sacral plexus and abdominal pain (p < 0.05, R 2 = 0.07).Conclusions:
Women treated with surgery and adjuvant radiotherapy for endometrial and cervical cancers have good QoL with minimal limitations of daily activities. QoL was correlated with dose-volume parameters such as bladder V40, mean dose to vagina, maximum dose to trigone and LSPRESUMEN
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Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.7 Universal access to health services related to reproductive and sexual health
/
SDG3 - Health and Well-Being
Health problem:
Sexually Transmitted Infections: Prevention and Care
/
Target 3.8 Achieve universal access to health
Database:
IBECS
Main subject:
Uterine Cervical Neoplasms
/
Endometrial Neoplasms
/
Radiotherapy, Adjuvant
Type of study:
Qualitative research
Aspects:
Patient-preference
Limits:
Female
/
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article
Institution/Affiliation country:
University Hospital Maggiore della Carità/Italy
/
University Hospital Maggiore della Caritá/Italy
/
University of Piemonte Orientale/Italy