Signaling and molecular basis of bone marrow niche angiogenesis in leukemia
Clin. transl. oncol. (Print)
; 18(10): 957-971, oct. 2016. tab, ilus
Article
in English
| IBECS
| ID: ibc-155958
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Angiogenesis, the process of blood vessel formation, is necessary for tissue survival in normal and pathologic conditions. Increased angiogenesis in BM niche is correlated with leukemia progression and resistance to treatment. Angiogenesis can interfere with disease progression and several angiogenic (such as vascular growth factors) as well as anti-angiogenic factors (i.e. angiostatin) can affect angiogenesis. Furthermore, miRs can affect the angiogenic process by inhibiting angiogenesis or increasing the expression of growth factors. Given the importance of angiogenesis in BM for maintenance of leukemic clones, recognition of angiogenic and anti-angiogenic factors and miRs as well as drug resistance mechanisms of leukemic blasts can improve the therapeutic strategies. We highlight the changes in angiogenic balance within the BM niche in different leukemia types. Moreover, we explored the pathways leading to drug resistance in relation to angiogenesis and attempted to assign interesting candidates for future research (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Leukemia
/
Bone Marrow Neoplasms
/
Stem Cell Niche
/
Neovascularization, Pathologic
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article
Institution/Affiliation country:
Ahvaz Jundishapur University of Medical Sciences/Iran
/
Semnan University of Medical Sciences/Iran
/
University Medical Center Groninge/The Netherlands