Epidemiological characteristics of a Spanish cohort of patients diagnosed with squamous cell carcinoma of head and neck: distribution of risk factors by tumor location
Clin. transl. oncol. (Print)
; 18(11): 1114-1122, nov. 2016. tab
Article
in English
| IBECS
| ID: ibc-156877
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Purpose. Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. Methods/patients. A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012-2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. Results. Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10-140 g OR 2.53, p = 0.012; 141-280 g OR 2.47, p = 0.023; >280 g OR 3.20, p = 0.001) and less associated with pack-years of smoking (21-40 packs OR 0.46, p = 0.045; 41-70 packs OR 0.43, p = 0.023; ≥71 packs OR 3.20, p = 0.015). Conclusions. The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Squamous Cell
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Laryngeal Neoplasms
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Risk Factors
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Head and Neck Neoplasms
Type of study:
Diagnostic study
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Etiology study
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Incidence study
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Observational study
Limits:
Adult
/
Aged
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Female
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Humans
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Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article
Institution/Affiliation country:
Carlos III Institute of Health/Spain
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Hospital Costa del Sol/Spain
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Hospital Miguel Servet/Spain
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Hospital Parc Tauli/Spain
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Hospital Universitario Lucus Augusti/Spain
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Hospital Universitario Politécnico La Fe/Spain
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Universitat de Barcelona/Spain
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University Hospital of Salamanca/Spain