Primary eosinophilic gastrointestinal disorders in children who have received food oral immunotherapy
Allergol. immunopatol
; 44(6): 531-536, nov.-dic. 2016. graf, tab
Article
in English
| IBECS
| ID: ibc-157874
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL ANDMETHODS:
A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg. When these children present persistent gastrointestinal symptoms, they are referred to the Paediatric Gastroenterology Unit for evaluation.RESULTS:
Primary eosinophilic gastrointestinal disorders were diagnosed in eight of the 128 cases of OIT (6.25%). The time to PEGDs development was variable two cases showed symptoms during OIT, and the rest with a median time of 29 months (15-48 months). Food treatment discontinuation was not required in four of the five cases of eosinophilic oesophagitis, although food removal was necessary in patients with eosinophilic gastroenteritis.CONCLUSIONS:
We report the highest prevalence of PEGDs in children subjected to OIT, and the first cases of eosinophilic gastroenteritis following food OIT. The monitoring of new digestive signs and symptoms after OIT is crucial for the diagnosis of these disorders, and prolonged follow-up is required. The management of such patients and the need or not to eliminate the food should be assessed on an individualised basis, according to the severity of the condition, its evolution and response to different treatment alternativesRESUMEN
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Collection:
National databases
/
Spain
Health context:
Neglected Diseases
Health problem:
Diarrhea
/
Zoonoses
Database:
IBECS
Main subject:
Desensitization, Immunologic
/
Eosinophilia
/
Eosinophilic Esophagitis
/
Gastrointestinal Diseases
Type of study:
Observational study
Limits:
Child
/
Child, preschool
/
Humans
Language:
English
Journal:
Allergol. immunopatol
Year:
2016
Document type:
Article
Institution/Affiliation country:
Rey Juan Carlos Universitary Hospital/Spain
/
Severo Ochoa Universitary Hospital/Spain
/
Villalba General Hospital/Spain