Utility of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome: importance of risk classification
Clin. transl. oncol. (Print)
; 19(1): 111-118, ene. 2017. tab, ilus
Article
in English
| IBECS
| ID: ibc-159125
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Purpose. To assess the diagnostic impact of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome (PNS) based on our own pre-test risk classification (PRC). Methods. A multicenter retrospective longitudinal study was conducted from 2006 to 2014. We designed a seven-point scoring system using the clinical syndrome characteristics [classical (CS) and non-classical syndromes (NCS)] and its location (central, peripheral, in the neuromuscular junction or combined), onconeural antibodies and tumor markers. Patients were classified as low (score 0-2), intermediate (3-4) and high (5-7) pre-test risk of PNS. FDG-PET/CT was classified as negative or positive. Final diagnosis according Graus criteria (definite, possible or no PNS) was established. Relations between clinical and metabolic variables with the final diagnosis were studied. Results. 73 patients were included, with a follow-up time of 33 months. Eleven (15 %) patients were finally diagnosed with neoplasm (8 invasive cancers). Ultimately, 13 (18 %) and 24 (33 %) subjects were diagnosed as definite or possible PNS. All the patients with final diagnosis of neoplasm had a CS (p = 0.005). PET/CT was helpful to diagnose 6/8 (75 %) invasive cancers. PET/CT findings were associated with the final diagnosis of neoplasm (p = 0.003) and the diagnosis of PNS attending to Graus criteria (p = 0.019). PRC showed significant association with the final diagnosis of neoplasm and PET/CT results. A majority of patients (10/11) diagnosed of neoplasm had intermediate/high-risk. Conclusions. Our PRC seems to be a valid tool to select candidates for PET/CT imaging in this setting. PET/CT detected malignancy in a significant proportion of patients with invasive cancer (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Fluorodeoxyglucose F18
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Paraneoplastic Syndromes, Nervous System
Type of study:
Controlled clinical trial
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Etiology study
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Observational study
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Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2017
Document type:
Article
Institution/Affiliation country:
Castilla La Mancha University/Spain
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Mancha Centro Hospital/Spain
/
Puertollano Hospital/Spain
/
University General Hospital/Spain
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University Hospital/Spain
/
Virgen de la Salud Hospital/Spain