Long-term survival in advanced non-squamous NSCLC patients treated with first-line bevacizumab-based therapy
Clin. transl. oncol. (Print)
; 19(2): 219-226, feb. 2017. tab, graf
Article
in English
| IBECS
| ID: ibc-159455
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background/Aim. First-line bevacizumab-based therapies have been shown to improve clinical outcomes in patients with non-squamous non-small-cell lung cancer (NSCLC). We aimed to descriptively analyse patients with non-squamous NSCLC who received a long-term period of maintenance bevacizumab. Patients and methods. This retrospective study included 104 patients who had already reached a progression-free survival (PFS) of at least 9 months. Results. Median overall survival and PFS were 30.7 and 15.1 months, respectively. The overall response rate was 83 %. Weight loss ≤5 %, ECOG PS = 0, or low number of metastatic sites seem to be predictive factors of good evolution. The incidence of bevacizumab-related adverse events appeared to be similar as the previous studies. Conclusion. Our findings show that there is a long-term survivor group whom the administration of bevacizumab resulted in a relevant prolongation of response without new safety signals. Due to the population heterogeneity, it was not possible to identify the standardised predictive factors (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Non-Small-Cell Lung
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Maintenance Chemotherapy
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Bevacizumab
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Survivorship
Type of study:
Observational study
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Prognostic study
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Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2017
Document type:
Article
Institution/Affiliation country:
Centro Integral Oncológico Clara Campal/Spain
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Complejo Asistencial Universitario de León/Spain
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Complejo Hospitalario Torrecárdenas/Spain
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Complejo Hospitalario de Jaén/Spain
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Complejo Hospitalario de Navarra/Spain
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Complexo Hospitalario Universitario de Vigo/Spain
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Fundación Jiménez Díaz/Spain
/
Hospital Arnau Vilanova/Spain
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Hospital Clínico Universitario Lozano Blesa/Spain
/
Hospital Clínico Universitario San Carlos/Spain