Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: A double blinded crossover study
Med. oral patol. oral cir. bucal (Internet)
; 22(1): e122-e131, ene. 2017. tab, graf
Article
in English
| IBECS
| ID: ibc-159777
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. MATERIAL ANDMETHODS:
Parameters were analyzed self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling.RESULTS:
Female volunteers reported significantly more postoperative pain at 1, 1.5, 2, 3 and 4hrs after surgery while also taking their first rescue medication at a time significantly earlier when consuming NE when compared to naproxen (3.7hrs and 6.7hrs). Conversely, no differences were found between each drug group in males.CONCLUSIONS:
In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pain, Postoperative
/
Naproxen
/
Esomeprazole
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2017
Document type:
Article
Institution/Affiliation country:
University of São Paulo/Brazil