Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes
Med. oral patol. oral cir. bucal (Internet)
; 22(2): e242-e250, mar. 2017. ilus, tab
Article
in English
| IBECS
| ID: ibc-161243
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2 ) plus silicon dioxide (SiO2 ) layers for guided bone regeneration (GBR) processes. MATERIAL ANDMETHODS:
Circumferential bone defects (diameter 11 mm; depth 3 mm) were created on the top of eight experimentation rabbits' skulls and were randomly covered with (1) PLGA membranes (control), or (2) PLGA/ PO2 /SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com a significance level of a=0.05 was considered.RESULTS:
The PLGA/PO2 /SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2 /SiO2 membranes predominantly showed bone layers in advanced stages of formation.CONCLUSIONS:
The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Plasma
/
Polyglactin 910
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Silicones
/
Guided Tissue Regeneration
Limits:
Animals
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2017
Document type:
Article
Institution/Affiliation country:
Cardiff University/United Kingdom
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Complutense University of Madrid (UCM)/Spain
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University of Seville/Spain
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Université Paris V - Descartes/Francia