Effect of phototherapy on B and T lymphocytes in Egyptian infants suffering from neonatal jaundice
Allergol. immunopatol
; 45(3): 290-296, mayo-jun. 2017. tab, ilus
Article
in English
| IBECS
| ID: ibc-162393
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Neonatal jaundice is one of the most common problems that affect newborn infants, and phototherapy is usually used for treatment.OBJECTIVES:
Evaluation of the effect of phototherapy on neonatal immune system through measuring the percentage of B and T lymphocytes and determining the frequency of development of infections and need for hospitalisation during the first six months of life.METHODS:
A prospective cohort study was conducted on 50 full term new-borns; 25 with indirect hyperbilirubinaemia and treated with conventional phototherapy and 25 healthy matched neonates as untreated controls. The percentages of CD19+, CD4+ and CD8+ lymphocytes were measured by flow cytometry before phototherapy and 72h after exposure. Follow-up of the study group for the occurrence of infections for a period of six months after phototherapy.RESULTS:
The study showed a significant difference in CD19+ lymphocytes percentage between patients before phototherapy and controls (P value<0.01), also a significant correlation between serum levels of total bilirubin in patients and CD19+ lymphocytes percentage (P value<0.05). There was no significant difference between the percentages of CD19+, CD4+ and CD8+ lymphocytes in patients before or after 72h of exposure to phototherapy (P value>0.05). Also, there was no correlation between the percentages of CD19+, CD4+ and CD8+ lymphocytes after 72h of exposure to phototherapy and the occurrence of infections (Gastrointestinal tract and Respiratory tract infection) after six months of follow-up (P value>0.05). More studies are needed with larger number of patients to determine the effect of phototherapy on immune systemRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Phototherapy
/
B-Lymphocytes
/
T-Lymphocytes
/
Hyperbilirubinemia
/
Immune System
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2017
Document type:
Article
Institution/Affiliation country:
Cairo University/Egypt
/
Shobra al Aam Hospital/Egypt