Allergenicity of vertebrate tropomyosins: challenging an immunological dogma
Allergol. immunopatol
; 45(3): 297-304, mayo-jun. 2017. graf, tab
Article
in English
| IBECS
| ID: ibc-162394
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
With the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Tropomyosin
/
Immunoglobulin E
/
Hypersensitivity
Type of study:
Practice guideline
Language:
English
Journal:
Allergol. immunopatol
Year:
2017
Document type:
Article
Institution/Affiliation country:
Instituto de Investigación Sanitaria-Hospital Universitario de La Princesa/Spain
/
Universidad Complutense/Spain