Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease / Los niveles de yodo están asociados con estrés oxidativo y estado antioxidante en mujeres embarazadas con enfermedad hipertensiva
Nutr. hosp
; 34(3): 661-666, mayo-jun. 2017. tab
Article
in English
| IBECS
| ID: ibc-164124
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported.Aim:
To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).Method:
Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women. Urinary iodine concentration (UIC), TSH, free T4 (fT4), total antioxidant status (FRP), superoxide dismutase (SOD), catalase (CAT), and oxidative stress (TBARS) were evaluated by colorimetric methods.Results:
UIC median for all pregnant women was 151.9 μg/l. The UIC for pregnant women with HPD was 50-149 μg/l, compared to 150-249 μg/l in normotensive women. No significant differences in levels of TSH and fT4 in normotensive pregnant compared with HPD women were found. Pregnant women with HPD had significant high levels of TBARS, and significant low levels of FRP, SOD, CAT and UIC compared to normotensive pregnant. In addition, pregnant women with optimal levels of UIC had a higher SOD activity (r = 0.354, p = 0.011), while iodine deficiency was associated with HPD (r = -0,281, p = 0.039). Similarly, pregnant women with HPD had a significant negative association with SOD activity (r = -0.702, p = 0.005), CAT (r = -0.409, p = 0.002), and FRP (r = -0.624, p = 0.003), and a positive association with TBARS (r = 0.744, p = 0.001).Conclusion:
Iodine contributes to redox balance during pregnancy; its deficiency is associated with HPD. This study shows the importance of iodine during pregnancy (AU)RESUMEN
Antecedentes previamente se han reportado la función antioxidante del yodo y su deficiencia como un factor de riesgo de preeclampsia. Objetivo:
analizar la asociación entre la deficiencia de yodo, el estrés oxidativo y el estado antioxidante con la enfermedad hipertensiva del embarazo (HPD).Métodos:
cincuenta y siete mujeres embarazadas se reclutaron en el último trimestre del embarazo, 20 diagnosticadas de enfermedad hipertensiva del embarazo y 37 gestantes normotensas. La concentración urinaria de yodo (UIC), TSH, T4 libre (hT4), estado antioxidante total (FRP), superóxido dismutasa (SOD), catalasa (CAT), y estrés oxidativo (TBARS) se evaluaron por métodos colorimétricos.Resultados:
la mediana de UIC para todas las mujeres embarazadas fue de 151,9 μg/l. La UIC para las mujeres embarazadas con HPD fue de entre 50 y 149 μg/l, comparada con 150-249 μg/l de las gestantes normotensas. No se encontraron diferencias significativas entre los niveles de TSH y fT4 en embarazadas normotensas y en mujeres con HPD. Las mujeres embarazadas con HPD tuvieron niveles altos de TBARS y niveles bajos de FRP, SOD, CAT y UIC comparadas con las gestantes normotensas. Además, las mujeres gestantes con niveles óptimos de UIC tuvieron la actividad SOD más alta (r = 0,354, p = 0,011), mientras que la deficiencia de yodo se asoció con HPD (r = -0,281, p = 0,039). De manera similar, las gestantes con HPD tuvieron una asociación negativa con la actividad de SOD (r = -0,702, p = 0,005), CAT (r = -0,409, p = 0,002) y FRP (r = -0,624, p = 0,003), y una asociación positiva con TBARS (r = 0,744, p = 0,001).Conclusión:
el yodo coadyuva en el balance redox durante la gestación; su deficiencia está asociada con HPD. Este estudio muestra la importancia del yodo durante la gestación (AU)
Full text:
Available
Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
IBECS
Main subject:
Pre-Eclampsia
/
Iodine Deficiency
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Case-Control Studies
/
Risk Factors
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Oxidative Stress
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Hypertension
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Antioxidants
Type of study:
Etiology study
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Observational study
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Risk factors
Limits:
Female
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Humans
/
Pregnancy
Language:
English
Journal:
Nutr. hosp
Year:
2017
Document type:
Article
Institution/Affiliation country:
Universidad Autónoma de Querétaro/México
/
Universidad Veracruzana/México
/
Universidad de Guadalajara/México