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The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia
Azizidoost, S; Vijay, V; Cogle, CR; Khodadi, E; Saki, N.
Affiliation
  • Azizidoost, S; Ahvaz Jundishapur University of Medical Sciences. Student Research Committee. Ahvaz. Iran
  • Vijay, V; University of Florida. College of Medicine. Department of Medicine. Division of Hematology and Oncology. Gainesville. USA
  • Cogle, CR; University of Florida. College of Medicine. Department of Medicine. Division of Hematology and Oncology. Gainesville. USA
  • Khodadi, E; Ahvaz Jundishapur University of Medical Sciences. Research Center of Thalassemia and Hemoglobinopathy. Health Research Institute. Ahvaz. Iran
  • Saki, N; Ahvaz Jundishapur University of Medical Sciences. Research Center of Thalassemia and Hemoglobinopathy. Health Research Institute. Ahvaz. Iran
Clin. transl. oncol. (Print) ; 19(9): 1059-1066, sept. 2017. ilus, tab
Article in English | IBECS | ID: ibc-165206
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed (AU)
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Collection: National databases / Spain Database: IBECS Main subject: Osteoblasts / Bone Marrow / Leukemia / Stem Cell Niche / Neoplasm Metastasis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / University of Florida/USA
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Collection: National databases / Spain Database: IBECS Main subject: Osteoblasts / Bone Marrow / Leukemia / Stem Cell Niche / Neoplasm Metastasis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/Iran / University of Florida/USA