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Adjuvant treatment for pancreatic ductal carcinoma
Macarulla, T; Fernández, T; Gallardo, ME; Hernando, O; López, AM; Hidalgo, M.
Affiliation
  • Macarulla, T; Hospital Vall d'Hebrón. Department Medical Oncology. Barcelona. Spain
  • Fernández, T; Hospital Son Llàtzer. Department Medical Oncology. Palma De Mallorca. Spain
  • Gallardo, ME; Complejo Hospitalario Universitario de Pontevedra. Department Medical Oncology. Pontevedra. Spain
  • Hernando, O; Hospital Universitario HM Sanchinarro. Department Radiation Oncology. Madrid. Spain
  • López, AM; Hospital Universitario de Burgos. Department Medical Oncology. Burgos. Spain
  • Hidalgo, M; Harvard Medical School. Beth Israel Deaconness Medical Center. Boston. USA
Clin. transl. oncol. (Print) ; 19(10): 1199-1204, oct. 2017. tab
Article in English | IBECS | ID: ibc-166152
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a very poor prognosis. Most of the patients are diagnosed in advanced stages of the disease, and 5-year survival rates in these patients remains <10%. Surgery still remains the only radical treatment option, although only 15-20% of patients are candidates for surgical resection at the time of the diagnosis. Patients who undergo radical surgery still have a limited survival rate, being the average of 23 months. Three clinical trials have shown that adjuvant chemotherapy therapy after surgery may improve survival CONKO-1, ESPAC-3, and ESPAC-4. Adjuvant therapy is recommended in patients with R0/R1, T1-4/N1-0 tumors and with ECOG 0-1. In patients with ECOG-2, the decision needs to be individualized. Treatment schemes that have demonstrated efficacy include gemcitabine alone, 5-fluorouracil, or the combination of gemcitabine and capecitabine for six months. Prior to adjuvant treatment, the following test are recommended Complete blood tests, including CA19.9 biomarker; imaging studies to rule out early disease relapse (preferable thorax-abdomen-pelvic CT). Studies that have evaluated the efficacy of radiation therapy in the adjuvant setting have presented conflicting results. Its use should be considered in patients with R1 or R2 tumors or in those with lymph nodes involved (AU)
RESUMEN
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Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Carcinoma, Pancreatic Ductal / Chemoradiotherapy, Adjuvant Type of study: Prognostic study Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Complejo Hospitalario Universitario de Pontevedra/Spain / Harvard Medical School/USA / Hospital Son Llàtzer/Spain / Hospital Universitario HM Sanchinarro/Spain / Hospital Universitario de Burgos/Spain / Hospital Vall d'Hebrón/Spain
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Collection: National databases / Spain Database: IBECS Main subject: Carcinoma, Pancreatic Ductal / Chemoradiotherapy, Adjuvant Type of study: Prognostic study Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Complejo Hospitalario Universitario de Pontevedra/Spain / Harvard Medical School/USA / Hospital Son Llàtzer/Spain / Hospital Universitario HM Sanchinarro/Spain / Hospital Universitario de Burgos/Spain / Hospital Vall d'Hebrón/Spain
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