Productos avanzados de oxidación proteica (PAOP) y su relación con los factores de riesgo cardiovascular en jóvenes aparentemente sanos / Advanced oxidation protein products and their relationship with cardiovascular risk factors in young apparently healthy people
Clín. investig. arterioscler. (Ed. impr.)
; 29(5): 209-215, sept.-oct. 2017. graf, tab
Article
in Spanish
| IBECS
| ID: ibc-166865
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
Introducción:
Los productos avanzados de oxidación proteica (PAOP) son un marcador para estimar estrés oxidativo en proteínas plasmáticas. El estrés oxidativo se considera un factor de riesgo cardiovascular (FRCV), relacionado con el aumento de presión arterial y la dislipidemia. Este trabajo tuvo por objetivo evaluar la asociación entre las concentraciones plasmáticas de PAOP y los FRCV en adultos jóvenes aparentemente sanos.Métodos:
Estudio transversal comparativo prospectivo en 120 estudiantes de la Facultad de Químico Farmacobiología de la UMSNH, a los que se les determinó IMC, presión arterial, así como PAOP, glucosa, colesterol total, lipoproteínas (de alta, baja y muy baja densidad) y triglicéridos.Resultados:
Los grupos de jóvenes con y sin FRCV presentaron diferencias significativas respecto a IMC, cintura, grasa corporal (p<0,05) y perfil lipídico (p<0,0001). Se presentaron cifras más altas de PAOP en el grupo de jóvenes con 3 y 4 FRCV (F 4,651; p=0,002). Los PAOP correlacionaron negativamente con el colesterol LDL (r=-0,364; p=0,0001).Conclusiones:
Se identificó que las concentraciones de PAOP se ven incrementadas conforme aumentan los FRCV en los jóvenes, por lo que estos podrían considerarse un factor importante de riesgo debido a que su depósito en la placa de ateroma favorece el proceso aterogénico y así el desarrollo de enfermedades cardiovasculares. La cuantificación de PAOP contribuye a la determinación indirecta del estado oxidativo en el organismo. El estudio del estado metabólico y oxidativo de jóvenes de aspecto saludable es de importancia en la prevención de enfermedades cardiovasculares en etapas posteriores de la vida, sin embargo, se requieren estudios longitudinales para estudiar su evolución (AU)ABSTRACT
Introduction:
Advanced oxidation protein products (AOPPs) are used as a marker to estimate oxidative stress in plasma proteins. Oxidative stress is considered a factor of cardiovascular risk (CVRF) related to increased blood pressure, and dyslipidaemia. The aim of this study was to evaluate the association between plasma AOPPs and CVRF in apparently healthy young adults.Methods:
A prospective cross-sectional study was conducted on 120 students of the Faculty of Chemical-Pharmacobiology of the UMSNH. Body mass index (BMI) and blood pressure were determined. A blood specimen was also collected to quantify AOPPs, glucose, total cholesterol, lipoproteins (high, low, and very low density), and triglycerides.Results:
Differences were observed in the groups with and without CVRF, with significant differences in BMI, waist, body fat (P<.05), and lipid profile (P<.0001). AOPPs were higher in the group of young people with three and four CVRF (F 4.651; P=.002). A negatively correlation was found between AOPPs and LDL cholesterol (r=-0.364; P=.0001).Conclusions:
It was observed that AOPPs concentrations are increased as CVRF increase in young adults. Thus, this could be considered an important risk factor, because their deposition in the atherosclerotic plaque favours the atherogenic process, and thus the development of cardiovascular disease. Quantification of AOPPs contributes to the indirect determination of oxidative status in the body. The study of metabolic and oxidative state of apparently healthy young adults is important in the prevention of cardiovascular disease in later life. More longitudinal studies are required to study its evolution (AU)
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Collection:
National databases
/
Spain
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
IBECS
Main subject:
Cardiovascular Diseases
/
Oxidative Stress
/
Advanced Oxidation Protein Products
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Spanish
Journal:
Clín. investig. arterioscler. (Ed. impr.)
Year:
2017
Document type:
Article
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/México