Immune response of toddlers with history of prematurity
Allergol. immunopatol
; 45(5): 425-431, sept.-oct. 2017. tab, graf
Article
in English
| IBECS
| ID: ibc-166995
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
It is not quite well established how immune responses differ in term and preterm infants beyond the first year of life. This study aimed to evaluate aspects of the innate and adaptive immune responses in a group of preterm infants in comparison with their term peers.Methods:
In this cross-sectional study peripheral blood mononuclear cells (PBMC) were isolated from preterm and term children at age three years. Innate immune response was evaluated by the analysis of TLR receptors expression on CD11c+HLADRhigh cells and inflammatory cytokine production after PBMC stimulation with Toll like receptors (TLR) ligands. Adaptive immune response was evaluated by T cells phenotyping and function after stimulation with polyclonal conventional T cell stimulus.Conclusion:
We have found that the patterns of innate and adaptive immune responses at 3 years of age were not affected by the fact of the children having being born preterm or at term (AU)RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Infant, Premature
/
Adaptive Immunity
/
Immunity, Innate
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2017
Document type:
Article
Institution/Affiliation country:
Laboratory of Cellular and Molecular Immunology/Brazil
/
Laboratory of Clinical and Experimental Immunology/Brazil
/
Laboratory of Pediatric Respirology/Brazil
/
Laboratory of Respiratory Physiology/Brazil