The role of active B cells in allergen immunotherapy
Allergol. immunopatol
; 45(5): 439-444, sept.-oct. 2017. tab
Article
in English
| IBECS
| ID: ibc-166997
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
The purpose of this study is to examine the changes in B lymphocyte subsets in patients receiving allergen immunotherapy.Methods:
B lymphocyte subsets of patients before immunotherapy and one year after immunotherapy began were examined using the flow cytometric method. Age-matched healthy children served as the control group.Results:
Twenty-two patients with asthma and/or allergic rhinitis and 14 healthy, age-matched controls were included in the study. The median age of the patients was 13 years old (range 6-20 years), and eleven (50.0%) were male. The median age of the healthy controls was also 13 years old (range 7-17), and seven (50.0%) were male. In the age group from 11 to 15 years; the patients relative and absolute counts of active and mature sensitive B cells were higher than those of the healthy children (p = 0.027-0.012 and p = 0.032-0.010, respectively) before immunotherapy. The relative and absolute counts of active B cells before immunotherapy were also significantly higher than those of after immunotherapy (p = 0.001-0.001, p = 0.025-0.037, and p = 0.029-0.035, respectively). Before immunotherapy, the relative and absolute counts of mature sensitive B cells were significantly higher than those obtained after immunotherapy (p = 0.024-0.006) in the 1115-year-old age group.Conclusions:
Allergen immunotherapy directly influences B cell differentiation and causes a decrease in the count of active B cells. This finding is relevant because the B cell count can be used as a guide in the assessment of an individual patient's treatment response and also when determining whether to continue the immunotherapy (AU)RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
B-Lymphocytes
/
Immunotherapy, Active
/
Hypersensitivity
Type of study:
Observational study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2017
Document type:
Article
Institution/Affiliation country:
Ondokuz Mayıs University/Turkey