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Long-term cardiovascular complications in stage I seminoma patients
Terbuch, A; Posch, F; Annerer, LM; Bauernhofer, T; Pichler, M; Szkandera, J; Hutterer, GC; Pummer, K; Partl, R; Kapp, KS; Stöger, H; Gerger, A; Stotz, M.
Affiliation
  • Terbuch, A; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Posch, F; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Annerer, LM; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Bauernhofer, T; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Pichler, M; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Szkandera, J; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Hutterer, GC; Medical University of Graz. Department of Urology. Graz. Austria
  • Pummer, K; Medical University of Graz. Department of Urology. Graz. Austria
  • Partl, R; Medical University of Graz. Department of Therapeutic Radiology and Oncology. Graz. Austria
  • Kapp, KS; Medical University of Graz. Department of Therapeutic Radiology and Oncology. Graz. Austria
  • Stöger, H; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Gerger, A; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
  • Stotz, M; Medical University of Graz. Department of Internal Medicine. Division of Clinical Oncology. Graz. Austria
Clin. transl. oncol. (Print) ; 19(11): 1400-1408, nov. 2017. tab, graf
Article in English | IBECS | ID: ibc-167122
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Purpose. The cure rate of stage I seminoma patients is close to 100% and so the recent focus of clinical research has shifted onto the prevention of treatment-related complications. We assessed long-term cardiovascular complications and identified risk factors for cardiovascular events (CVEs) in stage I seminoma patients. Methods. This retrospective cohort study included 406 consecutive stage I seminoma patients. Primary endpoint was CVE rate. Results. During a median follow-up of 8.6 years, we observed 23 CVEs in 406 patients [10-year CVE risk 5.6% (95% CI 3.2 to 8.8)]. In univariable competing risk analysis, higher age, positive smoking status, history of diabetes and hypertension were significantly associated with the occurrence of CVE. In multi-state analysis, new onset of diabetes, hypertension and hyperlipidemia during follow-up predicted for an excessively increased CVE risk. In multivariable analysis adjusting for age and smoking, the development of hypertension and hyperlipidemia after tumor-specific treatment prevailed as risk factors for CVE. Regarding adjuvant treatment modalities, patients receiving adjuvant radiotherapy had a significantly higher probability of CVE than patients receiving adjuvant carboplatin [16% vs. 0%; risk difference (RD) = 16%, 95% CI 6 to 25%, p = 0.001]. This difference prevailed after adjusting for age, follow-up-time, diabetes, hypertension and smoking (RD = 11%, 95% CI 1 to 20%, p = 0.025). Conclusion. We identified a panel of baseline risk factors and dynamically, occurring predictors of CVE in stage I seminoma patients. This information may be used for targeting comorbidity management in these patients. The observed association of adjuvant radiotherapy with higher CVE risk warrants further investigation (AU)
RESUMEN
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Subject(s)

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Cardiovascular Diseases / Carboplatin / Seminoma / Endpoint Determination Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Medical University of Graz/Austria

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Cardiovascular Diseases / Carboplatin / Seminoma / Endpoint Determination Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Clin. transl. oncol. (Print) Year: 2017 Document type: Article Institution/Affiliation country: Medical University of Graz/Austria
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