Tobacco nitrosamines as culprits in disease: mechanisms reviewed
J. physiol. biochem
; 72(1): 107-120, mar. 2016. ilus
Article
in English
| IBECS
| ID: ibc-168211
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
The link between tobacco abuse and cancer is well-established. However, emerging data indicate that toxins in tobacco smoke cause cellular injury due to enhanced toxic/metabolic effects of metabolites, disruption of intracellular signaling mechanisms, and formation of DNA, protein, and lipid adducts that impair function and promote oxidative stress and inflammation. These effects of smoking, which are largely non-carcinogenic, can be produced by tobacco-specific nitrosamines and their metabolites. These factors could account for the increased rates of neurodegeneration and insulin resistance diseases among smokers. Herein, we review nicotine and tobacco-specific nitrosamine metabolism, mechanisms of adduct formation, DNA damage, mutagenesis, and potential mechanisms of disease (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Nicotiana
/
Nitrosamines
Limits:
Humans
Language:
English
Journal:
J. physiol. biochem
Year:
2016
Document type:
Article
Institution/Affiliation country:
Rhode Island Hospital/USA